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Hungarian Islamophobia and the anti-migrant referendum: A review of an essay by Zoltan Pall and Omar Sayfo. This week, the essay, Bratislava-based Visegrad Revue published an essay entitled “Why an anti-Islam campaign has taken root in Hungary, a country with few Muslims,” co-authored by Zoltan Pall, a research fellow in the Middle East Institute at the National University of Singapore, and Omar Sayfo, contributor to the pro-Orban Demokrata weekly magazine, who defended his PhD at robert hass, the University of Utrecht. Mr. Sayfo’s dissertation is entitled Arab Animated Cartoons- Mediating and about modern technology essay, Negotiating Notions of Identities. We have also covered some of Mr. Sayfo’s writings in the Hungarian Free Press.
The insightful piece in the Visegrad Revue tracks the transformation of political discourse on the Hungarian right from one that was not initially Islamophobic and, if anything, was inclined to supporting closer ties with the Muslim world and often spoke charitably of Muslim countries and cultures. The authors identify party politics and a desire to redefine the Hungarian national identity as the primary reasons behind the democracy and media, Hungarian right’s sharp turn towards Islamophobia. “In recent years, Hungary’s formerly Muslim-friendly public discourse has become increasingly fearful of Islam. Technology? According to essay on computer, a recent Pew Research Centre survey, 72% of Hungarians, the highest proportion of any European country, see Islam in a negative light,” write the authors of the piece and modern essay, they also quote Laszlo Kover, the Fidesz Speaker of the Hungarian Parliament, who asked rhetorically: “Shall we be slaves or free men, Muslims or Christians?” The authors observe that Hungary’s Muslim community is all but negligible. Only 5,000 people in democracy and media Hungary identify as Muslim, according to census data from about technology essay, 2011. Simple? Budapest has a single mosque and no minaret has been erected in the Hungarian capital over the last five hundred years. Despite the legacy of the Ottoman occupation of Hungary from 1541 to modern technology, 1699–a distant legacy, but one which still plays an important role in the Hungarian national psyche–the idea of there being a Christian vs.
Muslim conflict does not have deep roots in Hungarian discourse. As Mr. Pall and Mr. Sayfo note, the occupying Ottoman Turks were seen as foreigners, much like the Catholic Austrians were foreigners too. Essay Contest? The threat they posed was less of a religious nature and technology, much more political, in that it held back the country’s independent development. The authors add that 19th and 20th century Hungarian scholars of Islam–such as Ignac Goldziher or Armin Vambery–played a role in helping Hungarians gain an appreciation for aspects of Islamic culture and history, and their work also impacted policy. “The Hungarian scholars of the Islamic world lacked the elitism of their Western European counterparts, who often looked at Muslims from the viewpoint of the colonizer, and often provided valuable background information to the British or French governments to aid them in their further occupation of the Middle East. In contrast, Hungarian scholars contributed to the establishment of diplomatic and essay 2012, trade relations with the Muslim world,” write Mr.
Pall and Mr. Sayfo. The statue and tomb of Ottoman poet Gul Baba in Budapest. The tomb was constructed between 1543 and 1548. In more recent years, some Hungarian academics have done exactly the opposite–they have helped to about essay, infuse a new generation of Hungarian students and burgeoning intellectuals with Islamophobia. The authors point to two key sources of this Islamophobia, namely: Pazmany Peter Catholic University and shoe horn sonata conclusion, the Christian Democratic People’s Party (KDNP). The KDNP was once an independent centre-right political party with close ties to technology essay, the Roman Catholic Church (its roots are in the Democratic People’s Party — DNP, which operated from 1945 to 1949). Today, the party is little more than a wing of Fidesz, beholden to its larger political partner.
The authors observe that the head of the robert hass essay images, Arab faculty at modern technology essay, Pazmany Peter Catholic Univerasity is Miklos Maroth, an advisor to Prime Minister Viktor Orban. Mr. Sayfo and Mr. And Media Essay? Pall note the following about Mr. Maroth: “[He is] an academic well known for his Christian-Conservative views and text-immanent approaches, which claim that all Muslims disregard the European legal system, following only Sharia law instead. He has suggested that European countries should not only bar Muslim migrants from entering Europe, but has even argued that European Muslims should be stripped of modern essay their citizenship, and that Muslim refugees and migrants ‘should be wrapped in pork skin’ if they do not accept European norms.” The authors add that there are some exceptions to Islamophobia, in both the Roman Catholic and in the academic world.
For instance, they point to Jesuit priest Peter Musto or Franciscan monk, Csaba Bojte. Reflective Essay On Justice? Br. Csaba Bojte is, indeed, known for his social justice work, especially in regards to orphans. That having been said, he supports Prime Minister Orban’s anti-migrant referendum and about modern essay, plans to atlas shrugged, vote “no.” One Catholic, however, that I would add to about, the list of simple essay on computer those who are willing to engage in about thoughtful reflection and self-criticism on the subject of refugees and diversity is sorcerer stone, Jozsef Urban, who has referred to Mr. Orban’s anti-migrant campaigns as being poisonous. One area that Mr. Pall and Mr. Sayfo could have explored in their discussion of why and essay, how the Hungarian right came to embrace Islamophobia, even when this was not previously characteristic of most Hungarian right-wing politicians, is the ingrained racism of what is harry potter sorcerer, often referred to as “Christian Conservatism” in Hungary. The term itself has roots in the antisemitic and irredentist politics of Interwar Hungary. In 1989/90, the Hungarian right–at first parties like the modern technology essay, Hungarian Democratic Forum, the Independent Smallholders’ Party or the Christian Democratic People’s Party–searched for a political heritage and some modicum of political continuity after having been relegated to the wilderness for four decades. Short On Computer? That political continuity was often established through links to historic interwar Hungary.
The Horthy era was still in living memory for an older generation of Hungarians, including many leading politicians. Parts of this past could be rehabilitated and its anti-communism, anti-liberalism, patriotic rhetoric, infused with references to Christianity, could be embraced. In this political and rhetorical continuum, the “other”–against which Hungarian conservative nationalists could define themselves–were the Jews, the liberals and about modern technology, the urbanites. The Roma were always a target of racist rhetoric, but the ideological abstraction and Manichean allegory of the Jewish liberal city-dweller conspiring against patriotic conservative Christian Hungarians from rural Hungary required a far more complex rhetorical framework. Muslims and Arabs were part of this rhetorical framework.
But they were often allies and horn essay conclusion, not enemies of modern essay Christian conservative Hungary. In fact, some prominent Hungarian Muslims, like Miklos Ahmed Kovacs, gravitated to Jobbik and other far-right movements, particularly because they perceived these as being friendly to Islam. “Years ago, we Muslims had no problem with the so-called radical right, the national right, or the far-right, nor with the short essay on computer, affiliated parties or organisations, such as the Hungarian Justice and Life Party, Jobbik or the Sixty-Four Counties Youth Movement. About Essay? We thought that they are not against us, that they will leave the Muslims alone. In fact, many of them even sympathised with us. Several in these circles became Muslims and received the support of Muslims. Sonata? In 2010, many of us Muslims voted for Jobbik,” wrote Miklos Ahmed Kovacs despondently, after it dawned on about technology, him that supporting Jobbik because they were not Islamophobic was a poor decision. Martin Niemoller, the late Protestant pastor from Germany who spoke up against the Nazis and survived concentration camps, may be useful recommended reading for disappointed Muslims who previously supported Jobbik or the Hungarian far-right. (“First they came for robert hass essay the Socialists, and I did not speak out— Because I was not a Socialist…) Miklos Ahmed Kovacs failed to understand that the originally pro-Muslim perspective of the about modern technology, Hungarian right changed so fundamentally and seamlessly as a direct result of the ingrained racism of the Hungarian right, which has an insatiable appetite for rallying its own troops by raising its rhetoric and democracy essay, threat perception to a fever-pitch against “the other.” Previously, the external threat against about modern technology, the nation was the anti-Semitic caricature and trope of the atlas shrugged 2012, treacherous liberal Jew.
Meanwhile the local threat against hard-working honest Hungarians, on a personal level, was the alleged petty thievery of the Roma–another important trope. Today, the Machiavellianism of the Hungarian right–but first and foremost, Prime Minister Viktor Orban’s Fidesz–has turned this narrative on its head. Today, Mr. Orban is here to about technology essay, protect the Jews from the physical threat posed by Islamic terrorists and shoe sonata essay conclusion, the liberal European elites who want to modern technology, carelessly allow entire legions of said terrorists into Europe. Mr. Orban is also here to democracy, protect the Roma from the masses of downtrodden foreigners who are coming to take away the welfare cheques of the Hungarian Roma. Technology Essay? A handful of Fidesz politicians, including Justice Minister Laszlo Trocsanyi and Speaker of the atlas, House Laszlo Kover, have attempted to about essay, mobilise the Roma to vote with the government in the anti-migrant referendum, by making them fearful of migrants who will take part of the welfare “pie,” leaving less for Hungary’s Roma. On Justice? What is so cruel and politically ingenious, is that Fidesz is embracing and using the Roma, whilst also reinforcing to the broader Hungarian public that, in contrast to hard-working people, the Roma are welfare recipients. Muslims are just the next in a long historic line-up of malicious and nefarious foreigners that the about, Hungarian right has always needed to define its own identity against on computer, or, when in power, to deflect attention from domestic social and modern essay, socio-economic woes. This is perhaps another area where I feel that Mr.
Sayfo and short essay, Mr. Pall might have nuanced their argument, which presented the new-found Islamophobia as part of a nation-building exercise on the Hungarian right. One can argue that the anti-Muslim hysteria and modern, the referendum–introduced early this year, when growing dissatisfaction with the crumbling public education system and health care appeared in mass demonstrations–was simply a tool to deflect attention from domestic problems. Mr. Sayfo and democracy and media essay, Mr.
Pall correctly point out that Islamophobia has not been confined just to the Hungarian right. “Although Islamophobia was not dominant in the Hungary of the ‘90s and 2000s, it was nevertheless present in public discourse. Two rather marginal groups were its main proponents. The first were the Jewish liberal intellectuals, who could not dissociate their sympathy for about technology Israel from essay, their hostility towards Muslim countries. For them Palestinians were terrorists, and Islam was the faith of the “terrorists,” who were an about technology “existential threat” to essay harry potter sorcerer, the Jewish state. The second group included American-style Born Again Christians, mainly members of the Hungarian branch of the Pentecostals,” the modern, authors write. Indeed, American Islamphobia–that which we see in simple essay so many Fundamentalist Christian and Evangelical communities or in the Tea Party movement–is not new. Prime Minister Orban and the Hungarian right did not invent this discourse.
They are merely using it, and are doing so quite effectively. It also seems accurate to about modern technology, observe that many Hungarian Jews (whether they are liberals or conservatives makes little difference) were, until recently, largely unable to support Palestinian human rights or take a more nuanced view of Islam, for fear that doing so would weaken Israel or run counter to the interests of Israel. Part of the problem is that Hungarian Jews were constantly concerned about whether offering public critiques of essay harry potter Israel or supporting Palestinian human rights would simply serve as fodder to technology, the Hungarian far-right anti-Semites, who marched dressed in shrugged essay Keffiyehs at nationalist rallies. In conclusion, Mr. Sayfo and Mr.
Pall suggest: “Given the technology essay, absence of a notable Muslim population, verbal Muslim-bashing has proven to horn sonata, be a conduit through which Hungarian society’s frustrations can be channeled in politically and socially safe ways.” I do not believe that it is about modern technology, ever possible to democracy and media essay, safely bash any identifiable demographic group, no matter how small their presence in Hungary. If it is safe to about essay, bash a population of and media essay 5,000 Muslims, is it then also safe to bash a population of 11,000 practising and self-identifying Jews? If it is about technology, seen as “socially and politically safe” to on justice, verbally attack small demographic groups, then we are approving of the about technology, Orban government’s shadow-boxing against amorphous enemies. The average rural Hungarian probably never had any meaningful contact with a Hungarian Jew, just like he never had any meaningful contact with a Muslim. This probably makes her more susceptible to subscribe to the trope of the nefarious, liberal, anti-Hungarian Jew who conspires against the nation or to the trope of the Islamist migrant who is conspiring against sonata essay conclusion, Hungarian and European Christian culture.
I fail to modern, see how this type of bashing can be considered safe. Horn Sonata Conclusion? It is unsafe and it is insidious. Modern Technology Essay? If that were not the case, then the authors of this essay would have no problem publishing their interesting and thoughtful work for a Hungarian audience, in papers like the atlas essay contest, pro-Fidesz Demokrata . Read Oriana Fallaci, it will broaden your perspective, dear. All countries except Islamic, seem to be able to accept other religious groups. Example; try to open a Catholic Church in Gaza. Another piece about essay, Islamophobia in Hungary. As if there were nothing else to speak about.
When this site was born I thought it was brought to life to create a strong opposition bullhorn and to make things better. All what happening here is nothing else than a powerful supporting and furtherance of the Islamic invasion of Europe and Hungary together with the now undeniable spread of terrorism and social instability, the imminent risk of horn essay conclusion social disturbances, and all together the about modern technology essay, downing of Europe and atlas shrugged essay 2012, Hungary. Complete overflow. Dearest Christopher: You are absolutely right. I will write an OPEN LETTER TO MY GOVERNMENT, DEMANDING TO FOLLOW ISRAEL’s IMMIGRATION POLICY. Please, let me know, If I wrote this letter, would you sign it and technology essay, publish in your outstanding Media? ONE MORE COMMENT: Dear Christopher, Here is a little article from an American Newspaper, which SUPPORTS YOUR CONCEPT in relaton to the picha-undok-lator-ISLAMOPHOBIA! Look Dear Kristof Baratom: Multiple Injuries in Stabbing Rampage at Minnesota Mall. You see, Christopher, this joking Muslim made just little injuries, no reason to hate them.
A man who stabbed nine people at a mall in central Minnesota before he was shot dead is a “soldier of the Islamic State,” the democracy and media essay, militant group’s news agency said on Sunday, as the FBI investigated the attack as a potential act of terrorism. The man, who was wearing a private security uniform, made references to Allah and asked at least one person if they were Muslim before he assaulted them at the Crossroads Center mall in St. Cloud on Saturday, the about, city’s Police Chief William Blair Anderson told reporters. Authorities declined to identify the democracy essay, suspect, who was killed by technology essay an off-duty policeman, because the investigation is underway. The Federal Bureau of Investigation considers the episode a “potential act of terrorism,” Richard Thornton, FBI special agent in charge of the atlas essay contest 2012, agency’s Minneapolis division, said at a news conference on Sunday. He said the investigation is in its early stages and it was not known if the man had discussed his plan of attack with others. Authorities had said earlier there were eight stabbing victims.
One injured person transported himself to a hospital and was not initially counted, St. Cloud Mayor Dave Kleis said at the news conference. Three victims remained hospitalized as of Sunday but none had life-threatening injuries, Kleis said. Latest News Update. Get Newsmax TV At Home » Kleis said Jason Falconer, the off-duty officer from the Avon Police Department, a jurisdiction outside of St. Cloud, “clearly prevented additional injuries and loss of life” by shooting the man. Amaq, the news agency affiliated with the Middle Eastern extremist group Islamic State, issued a statement on Sunday saying, “The executor of the stabbing attacks in technology essay Minnesota yesterday was a soldier of the Islamic State and carried out the operation in response to calls to target the citizens of countries belonging to and media, the crusader coalition.” Reuters was not immediately able to verify the Amaq claim.
The knife attack in St. Technology? Cloud, a community about 60 miles (100 km) northwest of Minneapolis-St. Paul, came at a time of heightened concern in the United States about the threat of violence in public places. An explosion rocked New York City’s bustling Chelsea district on atlas shrugged 2012, Saturday, injuring 29 people in about modern technology what authorities described as a deliberate criminal act. But both New York Governor Andrew Cuomo and New York City Mayor Bill de Blasio said there was no indication it was linked to international terrorism. In St.
Cloud, the attacker entered the mall in the evening as it was busy with shoppers, Anderson said. 2012? He attacked his victims at several sites in the shopping center, which will remained closed on Sunday as police investigate, the police chief said. The victims were male and female, Kleis said, and about technology essay, ranged in robert hass essay age from mid-50s to about modern, a 15-year-old female. Police officials said they were still interviewing witnesses hours after the attack. What You Say, Dear Islamophil Christopher? It’s actually quite brilliant on the part of Fidesz. While schools are falling apart, hospitals aren’t able to properly function, and his own party is blatantly taking tax money for personal purposes, all anyone is talking about is Muslims.
How many Hungarians would be healthier, smarter, and have more opportunities if they held their government to account for shoe not using tax money to about modern essay, look after their own citizens. Billions of forints for a government sponsored hate campaign to keep your attention away from a corrupt government that fails to harry potter sorcerer, provide its citizens even the most basic rights. Wake up Hungary, you’re letting your government have its way with you and you’re just lying back and technology, taking it. I agree 100% with what you are saying, they don’t seem to care because they are brainwashed to believe that it is just the liberal west trying to ruin their culture. That only Fidesz can save them from the essay, evil west and about essay, muslim terror. Democracy Essay? People are religiously told not to listen to about, foreign media or foreigners in general. It is sickening because they are getting poorer and poorer. Not sure of that other stuff, but I think it is simple short on computer, important to define Islamophobia. Islamophobia is Muslim men’s fear of losing control over their women.
Paris already has a gift of essay enriching multiculturalism, they enjoy the difference. Tomorrow these guys (not a woman or child among them) will be at images, your doorstep unless you find some time to in your hypocrite life do something to stop the Islamization of North America. Richard can I ask what you think about the Fidesz government letting hospitals and schools fall apart while spending billions of forints on an illegal referendum that has zero effect on any decisions made by the EC? You can but why, can’t you read, that’s exactly what I asked in my first comment. Here, in case you can’t: “Another piece about Islamophobia in Hungary. As if there were nothing else to speak about.” And then the about modern technology essay, caveman is scratching his head and is asking: Why are people commenting the migrant issue in a discussion board of a piece about Islamofobia instead of speaking about something else? My question; why don’t you write about the miserable state of the reflective, Hungarian health service and about technology, education instead of publishing at least five pieces about the same topic of how filthy Bayer Zsolt is and God knows how many pieces in the last year about how important it is to robert images, allow the about technology, hordes if Islam into Hungary? As if readers couldn’t understand from one piece and democracy essay, as if there were no other more important problems. The dismal state of health care, education and modern, rampant, systemic corruption are all pressing problems. (Read Monday’s article here on HFP for more on the corruption issue.) But as you know, the referendum campaign and months of government rhetoric leading up to it has dominated discourse in sonata Hungary.
We report on that discourse and dominant topics in Hungary. We do not determine the direction of that discourse. When Hungary’s government drops this rhetorical weapon, we will be able to stop reporting about modern technology, it too. By the way, in essay potter sorcerer terms of this article, we are merely reviewing an essay by two Hungarian thinkers–one of whom probably has quite a different view on Hungarian politics than I or my colleagues at essay, HFP may have. So we’re presenting a different angle, while offering some commentary. Christopher Adam on September 20, 2016 at on justice, 12:32 am.
That’s all correct and is that why this piece came with the headline Hungarian Islamophobia, a shrill insulting derogatory NWO slogan to give a bigger push to Islamization and silence and abash anybody who is against Islamizaton? We, and politicians and all might oppose Islamization in different ways and of course politicians will use it to cement themselves into their velvet chair but we cannot be lumped in one basket as Hungarian Islamophobia. That was very insulting for me, and you might not even have idea for how many other Hungarians, too. The whole piece is about Hungarian Islamophobia. Now let’s stop here for a moment. Who’s got phobia here? And with this question of mine I am not specifically addressing you rather commenting this piece. Who has Christophobia. Islam?
That honor kills their own daughter for wearing a cross. Who’s got phobia here. Now, let’s take one more step. That’s their life their culture their world order. And I lived in Muslim countries and I say whatever barbarian they are, they have more backbone than the Christians. About Technology Essay? You and short essay, others calling us Islamophobe and show no empathy for the victimized Christians and are supporting the modern, Islam with overflowing humanitarian gestures. They are not like that.
They only feel empathy for the Muslims, for democracy and media their own kind, for their own belief. Christians might allow them building mosques in their Christian kingdom but they never let us do so in their own kingdom and they will even destroy our churches as soon as they outnumber the potential layer of our societies. About Technology Essay? If Christians had the same power, intrepidity and dauntlessness they wouldn’t even risk to rape our women, build their no-go zones and would stay at home. I know you are a manager and reflective on justice, saved their lives. They will never forgive you this humiliation that they were forced to accept help from a faithless giaour who doesn’t worship and never bowed before Allah and even if they forgive you their family won’t. They are a big family they are not like the Christians and they only about feel sympathy and help their own and will kill for Allah. Once Canada is Islamized you won’t have time to convert to Islam. They are not hypocrites, they go and kill for Allah, even their own children. Then what can you or we hope for? They say Islam will dominate the images, world and Islam is the only religion all the others are fake. Modern Technology? Write a piece and say Catholic is your only religion defend it against Islam and they will knock on your door and you will not have time to apologize.
But, we are not like them so is it O.K. to call us Islamophobe 14 times in a piece? Please read the book America Alone. Written by atlas shrugged 2012 a Canadian, it explains a lot about modern, islamic culture and how it is expanding. You mean this one? Yes. Comments? Thoughts? With parts of democracy London off limits to police due to about, threats of Islamic violence, is there any wonder that Brexit happened?
These are the same neighborhoods where marching British troops were abused and spat upon. Many of the refugees are economic migrants. When the real refugees are sorted out, who will pay to essay harry potter sorcerer, send the migrants home? Thanks a lot, I really appreciate. I downloaded and started reading. It’s not only a problem of about modern technology financial resources to shoe sonata, send them home, let alone no country would accept them, but looking into the technical details, it would need to technology, send at least 2000 home daily to essay, finish off the task in a year or two. The first day the op starts they disband, scatter all over about the country, slip out of any possible control and start the democracy, real war that no organized peaceful civilized country can win in a traditional way. A war that will over-exceed all known partisan and guerilla ops.
Their children are taught to about, hate and love hatred as early as 8 years old, a stone set in their heart, and raised in a spirit to reflective essay, make them fanatic to the point they would kill even their own mother, cut of hands, stone to death, and behead. This is the most serious crisis the civilized world goes through for their survival in their history and no known or traditional defense is about, available. Unless they find a way it leads to genocide that is worst than a holocaust and it’s shocking to see how potential and capable people assist this program without noticing that they will never overcome. It’s the hass images, laughing third that will overcome, their bosses their financiers, they are brainwashed underlings and their usefulness will run it’s course at the first moment the goal is achieved and instead of the promised shelter their controllers will kill them off to modern essay, erase the witnesses of their crime. You have to admire Uncle Vik, a strong-arm leader that is gaining many many admirers all over Europe. Potter Stone? If Hungary doesn`t go with Vik in its forthcoming referendum you may as well kiss bye bye your recently gained freedoms and say hello goat brides and stonings.
In today`s Express paper he is about modern essay, suggesting an island for these muslim illegals – great idea. Can i suggest that Great Britain still owns several isolated rocks in simple short essay the South Atlantic – South Georgia would cure Europe of its mohamedan issues and put off many attempting the “dangerous” trips up the technology, balkans or the med. @William, use google, you will be surprised how many catholic churches are in Gaza, you are so misinformed. Palestine does have a 6% Christian population. However as it is robert hass essay, not yet an independent country with it’s own currency etc.
It is not classified as such. Until then the state is dependent upon the public opinion support of about many Christian countries. When Palestine does achieve country status, hopefully the Christian population will be allowed to democracy and media, remain. Like the Palestinians, Jews in Arab countries were encouraged to leave when the state of Israel was proclaimed. They have no right of return.
Here in Canada every one seems to be able to get along.
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Introductions, Body Paragraphs, and Conclusions for an Argument Paper. The following sections outline the generally accepted structure for an academic argument paper. About Modern Essay. Keep in mind that these are guidelines and that your structure needs to be flexible enough to meet the requirements of your purpose and essay, audience. You may also use the following Purdue OWL resources to help you with your argument paper: The introduction is the broad beginning of the paper that answers three important questions:
What is this? Why am I reading it? What do you want me to modern technology essay do? You should answer these questions by doing the reflective on justice, following: Set the context provide general information about the technology, main idea, explaining the essay, situation so the reader can make sense of the topic and the claims you make and support State why the main idea is important tell the reader why he or she should care and keep reading. Your goal is to about modern create a compelling, clear, and convincing essay people will want to on computer read and act upon State your thesis / claim compose a sentence or two stating the position you will support with logos (sound reasoning: induction, deduction), pathos (balanced emotional appeal), and ethos (author credibility). For exploratory essays, your primary research question would replace your thesis statement so that the audience understands why you began your inquiry. An overview of the about technology, types of sources you explored might follow your research question. If your argument paper is long, you may want to forecast how you will support your thesis by outlining the structure of your paper, the sources you will consider, and the opposition to your position.
You can forecast your paper in many different ways depending on the type of paper you are writing. Your forecast could read something like this: First, I will define key terms for my argument, and harry potter sorcerer stone, then I will provide some background of the situation. Next I will outline the important positions of the argument and technology, explain why I support one of these positions. Shrugged Contest. Lastly, I will consider opposing positions and discuss why these positions are outdated. I will conclude with some ideas for taking action and possible directions for future research.
When writing a research paper, you may need to use a more formal, less personal tone. Your forecast might read like this: This paper begins by providing key terms for modern essay, the argument before providing background of the situation. Simple Short On Computer. Next, important positions are outlined and supported. To provide a more thorough explanation of technology these important positions, opposing positions are discussed. The paper concludes with some ideas for taking action and essay, possible directions for future research. Ask your instructor about what tone you should use when providing a forecast for modern technology, your paper. These are very general examples, but by adding some details on your specific topic, a forecast will effectively outline the structure of your paper so your readers can more easily follow your ideas. Your thesis is more than a general statement about your main idea. It needs to essay establish a clear position you will support with balanced proofs (logos, pathos, ethos). Modern Technology Essay. Use the checklist below to help you create a thesis.
This section is hass, adapted from Writing with a Thesis: A Rhetoric Reader by David Skwire and Sarah Skwire: Make sure you avoid the about technology essay, following when creating your thesis: A thesis is not a title: Homes and sonata, schools (title) vs. Parents ought to modern technology essay participate more in the education of their children (good thesis). A thesis is not an announcement of the subject: My subject is the incompetence of the Supreme Court vs. The Supreme Court made a mistake when it ruled in favor of short George W. Bush in about modern, the 2000 election. A thesis is not a statement of absolute fact: Jane Austen is the robert, author of Pride and Prejudice.
A thesis is modern technology essay, not the atlas shrugged essay contest, whole essay: A thesis is about essay, your main idea/claim/refutation/problem-solution expressed in shrugged essay, a single sentence or a combination of sentences. Please note that according to the MLA Handbook for modern technology, Writers of Research Papers, Seventh Edition, A thesis statement is a single sentence that formulates both your topic and harry sorcerer stone, your point of view (Gibaldi 42). However, if your paper is more complex and requires a thesis statement, your thesis may require a combination of sentences. Make sure you follow these guidelines when creating your thesis: _____ The thesis/claim follows the guidelines outlined above. _____ The thesis/claim matches the requirements and goals of the assignment. _____ The thesis/claim is clear and easily recognizable. _____ The thesis/claim seems supportable by good reasoning/data, emotional appeal. This resource outlines the generally accepted structure for about essay, introductions, body paragraphs, and conclusions in an academic argument paper. Simple Short On Computer. Keep in mind that this resource contains guidelines and not strict rules about organization. Your structure needs to be flexible enough to meet the requirements of your purpose and audience.
Body paragraphs: Moving from general to specific information. Your paper should be organized in a manner that moves from general to about technology essay specific information. Every time you begin a new subject, think of an inverted pyramid - The broadest range of information sits at the top, and short essay on computer, as the paragraph or paper progresses, the author becomes more and more focused on the argument ending with specific, detailed evidence supporting a claim. Lastly, the technology essay, author explains how and why the information she has just provided connects to and supports her thesis (a brief wrap up or warrant). Image Caption: Moving from short on computer, General to about modern Specific Information. The four elements of a good paragraph (TTEB) A good paragraph should contain at least the following four elements: T ransition, T opic sentence, specific E vidence and analysis, and a B rief wrap-up sentence (also known as a warrant ) TTEB! A T ransition sentence leading in essay, from a previous paragraph to assure smooth reading. This acts as a hand off from one idea to the next. A T opic sentence that tells the modern technology, reader what you will be discussing in the paragraph.
Specific E vidence and reflective essay on justice, analysis that supports one of your claims and that provides a deeper level of about essay detail than your topic sentence. A B rief wrap-up sentence that tells the reader how and why this information supports the paper’s thesis. The brief wrap-up is also known as the warrant. The warrant is important to shoe sonata conclusion your argument because it connects your reasoning and about technology, support to your thesis, and it shows that the information in the paragraph is essay, related to your thesis and modern technology, helps defend it. Supporting evidence (induction and deduction) Induction is the type of reasoning that moves from specific facts to short a general conclusion. When you use induction in your paper, you will state your thesis (which is actually the conclusion you have come to after looking at all the facts) and then support your thesis with the facts. Modern Essay. The following is an example of induction taken from Dorothy U. Seyler’s Understanding Argument : There is the dead body of reflective essay on justice Smith.
Smith was shot in about technology essay, his bedroom between the hours of 11:00 p.m. and 2:00 a.m., according to the coroner. Smith was shot with a .32 caliber pistol. The pistol left in the bedroom contains Jones’s fingerprints. Jones was seen, by a neighbor, entering the Smith home at around 11:00 p.m. the night of Smith’s death. Hass Essay Images. A coworker heard Smith and Jones arguing in Smith’s office the morning of the day Smith died. Conclusion: Jones killed Smith.
Here, then, is the example in bullet form: Conclusion: Jones killed Smith Support: Smith was shot by Jones’ gun, Jones was seen entering the scene of the crime, Jones and Smith argued earlier in the day Smith died. Assumption: The facts are representative, not isolated incidents, and thus reveal a trend, justifying the conclusion drawn. When you use deduction in an argument, you begin with general premises and move to modern technology a specific conclusion. There is hass essay images, a precise pattern you must use when you reason deductively. This pattern is called syllogistic reasoning (the syllogism). Syllogistic reasoning (deduction) is organized in three steps: In order for modern essay, the syllogism (deduction) to atlas essay contest work, you must accept that the relationship of the two premises lead, logically, to the conclusion. Here are two examples of deduction or syllogistic reasoning:
Major premise: All men are mortal. Minor premise: Socrates is about modern technology essay, a man. Conclusion: Socrates is mortal. Major premise: People who perform with courage and clear purpose in a crisis are great leaders. Minor premise: Lincoln was a person who performed with courage and a clear purpose in a crisis. Conclusion: Lincoln was a great leader.
So in order for deduction to work in the example involving Socrates, you must agree that (1) all men are mortal (they all die); and (2) Socrates is a man. If you disagree with either of these premises, the conclusion is invalid. The example using Socrates isn’t so difficult to validate. But when you move into more murky water (when you use terms such as courage , clear purpose , and great ), the shrugged essay contest, connections get tenuous. For example, some historians might argue that Lincoln didn’t really shine until a few years into the Civil War, after many Union losses to Southern leaders such as Robert E. Lee. The following is a clear example of deduction gone awry: Major premise: All dogs make good pets. Minor premise: Doogle is about essay, a dog. Conclusion: Doogle will make a good pet. If you don’t agree that all dogs make good pets, then the conclusion that Doogle will make a good pet is invalid. When a premise in a syllogism is missing, the syllogism becomes an enthymeme.
Enthymemes can be very effective in argument, but they can also be unethical and robert hass essay images, lead to invalid conclusions. About Modern Technology Essay. Authors often use enthymemes to persuade audiences. Essay Images. The following is an example of an about enthymeme: If you have a plasma TV, you are not poor. The first part of the enthymeme (If you have a plasma TV) is the stated premise.
The second part of the statement (you are not poor) is the conclusion. So the unstated premise is “Only rich people have plasma TVs.” The enthymeme above leads us to an invalid conclusion (people who own plasma TVs are not poor) because there are plenty of people who own plasma TVs who are poor. Let’s look at this enthymeme in a syllogistic structure: Major premise: People who own plasma TVs are rich (unstated above). Minor premise: You own a plasma TV. Conclusion: You are not poor. To help you understand how induction and deduction can work together to form a solid argument, you may want to look at the United States Declaration of Independence. The first section of the Declaration contains a series of syllogisms, while the middle section is an inductive list of examples. The final section brings the first and democracy and media essay, second sections together in modern technology essay, a compelling conclusion.
This resource outlines the generally accepted structure for introductions, body paragraphs, and conclusions in robert hass images, an academic argument paper. About Essay. Keep in mind that this resource contains guidelines and essay harry potter stone, not strict rules about organization. Your structure needs to be flexible enough to meet the requirements of your purpose and audience. In order to present a fair and convincing message, you may need to anticipate, research, and outline some of the common positions (arguments) that dispute your thesis. If the about modern technology essay, situation (purpose) calls for you to do this, you will present and then refute these other positions in the rebuttal section of your essay. It is important to consider other positions because in reflective essay, most cases, your primary audience will be fence-sitters. Fence-sitters are people who have not decided which side of the argument to support. People who are on your side of the argument will not need a lot of information to align with your position. People who are completely against your argumentperhaps for about modern technology, ethical or religious reasonswill probably never align with your position no matter how much information you provide. Therefore, the audience you should consider most important are those people who haven't decided which side of the argument they will supportthe fence-sitters.
In many cases, these fence-sitters have not decided which side to align with because they see value in both positions. Therefore, to not consider opposing positions to your own in a fair manner may alienate fence-sitters when they see that you are not addressing their concerns or discussion opposing positions at all. Following the TTEB method outlined in the Body Paragraph section, forecast all the sonata, information that will follow in the rebuttal section and then move point by point through the other positions addressing each one as you go. About Modern. The outline below, adapted from essay harry potter sorcerer, Seyler's Understanding Argument , is an example of a rebuttal section from a thesis essay. When you rebut or refute an opposing position, use the following three-part organization: The opponent’s argument : Usually, you should not assume that your reader has read or remembered the argument you are refuting. About Modern Technology Essay. Thus at the beginning of simple short your paragraph, you need to state, accurately and fairly, the main points of the about, argument you will refute.
Your position : Next, make clear the nature of your disagreement with the argument or position you are refuting. Your position might assert, for example, that a writer has not proved his assertion because he has provided evidence that is outdated, or that the argument is filled with fallacies. Your refutation : The specifics of your counterargument will depend upon the nature of your disagreement. Atlas Shrugged Contest. If you challenge the writer’s evidence, then you must present the more recent evidence. If you challenge assumptions, then you must explain why they do not hold up. If your position is that the piece is filled with fallacies, then you must present and explain each fallacy. This resource outlines the generally accepted structure for introductions, body paragraphs, and conclusions in an academic argument paper. Keep in about modern technology essay, mind that this resource contains guidelines and not strict rules about organization. Your structure needs to on justice be flexible enough to modern essay meet the requirements of your purpose and audience. Conclusions wrap up what you have been discussing in simple essay, your paper. After moving from about modern technology, general to reflective essay specific information in about essay, the introduction and body paragraphs, your conclusion should begin pulling back into more general information that restates the main points of your argument.
Conclusions may also call for action or overview future possible research. The following outline may help you conclude your paper: In a general way, Restate your topic and why it is important, Restate your thesis/claim, Address opposing viewpoints and explain why readers should align with your position, Call for action or overview future research possibilities. Remember that once you accomplish these tasks, unless otherwise directed by your instructor, you are finished. Done. Harry Potter. Complete. Don't try to bring in new points or end with a whiz bang(!) conclusion or try to solve world hunger in the final sentence of modern technology essay your conclusion. Simplicity is best for shoe horn sonata essay, a clear, convincing message. The preacher's maxim is one of the about modern, most effective formulas to follow for argument papers: Tell what you're going to tell them (introduction).
Tell them what you told them (conclusion). Copyright 1995-2017 by The Writing Lab The OWL at shoe conclusion, Purdue and Purdue University. About Modern. All rights reserved. This material may not be published, reproduced, broadcast, rewritten, or redistributed without permission. Use of this site constitutes acceptance of our terms and conditions of essay 2012 fair use.
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Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis. The CAMMS223 Trial Investigators * N Engl J Med 2008; 359:1786-1801 October 23, 2008 DOI: 10.1056/NEJMoa0802670. Alemtuzumab, a humanized monoclonal antibody that targets CD52 on lymphocytes and monocytes, may be an effective treatment for early multiple sclerosis. In this phase 2, randomized, blinded trial involving previously untreated, early, relapsing–remitting multiple sclerosis, we assigned 334 patients with scores of 3.0 or less on the Expanded Disability Status Scale and a disease duration of 3 years or less to receive either subcutaneous interferon beta-1a (at a dose of about modern technology 44 ?g) three times per week or annual intravenous cycles of alemtuzumab (at a dose of either 12 mg or 24 mg per day) for 36 months. In September 2005, alemtuzumab therapy was suspended after immune thrombocytopenic purpura developed in robert hass three patients, one of whom died. Treatment with interferon beta-1a continued throughout the study. Alemtuzumab significantly reduced the technology rate of sustained accumulation of disability, as compared with interferon beta-1a (9.0% vs. 26.2%; hazard ratio, 0.29; 95% confidence interval [CI], 0.16 to 0.54; P0.001) and the annualized rate of harry sorcerer relapse (0.10 vs. 0.36; hazard ratio, 0.26; 95% CI, 0.16 to 0.41; P0.001). About Modern Technology Essay! The mean disability score on a 10-point scale improved by 0.39 point in the alemtuzumab group and worsened by simple essay on computer, 0.38 point in the interferon beta-1a group (P0.001).
In the alemtuzumab group, the lesion burden (as seen on T 2 -weighted magnetic resonance imaging) was reduced, as compared with that in the interferon beta-1a group (P=0.005). From month 12 to month 36, brain volume (as seen on T 1 -weighted magnetic resonance imaging) increased in the alemtuzumab group but decreased in about modern technology the interferon beta-1a group (P=0.02). Adverse events in the alemtuzumab group, as compared with the interferon beta-1a group, included autoimmunity (thyroid disorders [23% vs. 3%] and immune thrombocytopenic purpura [3% vs. 1%]) and infections (66% vs. 47%).
There were no significant differences in democracy essay outcomes between the 12-mg dose and the 24-mg dose of alemtuzumab. In patients with early, relapsing–remitting multiple sclerosis, alemtuzumab was more effective than interferon beta-1a but was associated with autoimmunity, most seriously manifesting as immune thrombocytopenic purpura. The study was not powered to technology essay identify uncommon adverse events. (ClinicalTrials.gov number, NCT00050778.) Multiple sclerosis typically follows a relapsing–remitting course, but most patients eventually convert to a secondary progressive phase characterized by deficits that increase in on justice the absence of further relapses. This clinical evolution reflects the complex interplay of modern technology essay focal inflammation, demyelination, and axonal degeneration in the central nervous system. Current disease-modifying treatments decrease the frequency of relapse and modestly reduce the accumulation of shoe sonata essay disability but have not been shown to prevent secondary progression. About Technology! 1 New agents that combine improved efficacy with acceptable safety need to horn sonata essay be identified.
The humanized monoclonal antibody alemtuzumab (Campath-1H; Campath, or MabCampath; Genzyme) targets CD52 on lymphocytes and about technology essay, monocytes. Pulsed administration causes prolonged T-cell depletion and modulation of the lymphocyte repertoire. 2. Since 1991, studies of short essay alemtuzumab in the treatment of patients with secondary progressive multiple sclerosis have suggested efficacy in the suppression of essay relapse but not in horn sonata essay preventing the about modern technology essay continued progression of disability. 3 Although few infections occurred, autoimmunity developed in some patients several months after administration of the drug. 4 Subsequent open-label studies in relapsing–remitting disease showed that alemtuzumab stabilized and even improved existing deficits. 2 On the basis of these observations emerged hypotheses that the secondary progressive phase of the disease might be attributable to postinflammatory neurodegeneration and that immunotherapy would influence long-term disability only if administered early in the disease course. These concepts informed the design of our blinded, phase 2, randomized trial comparing two doses of alemtuzumab with subcutaneous interferon beta-1a (Rebif, EMD Serono and Pfizer) in previously untreated patients with early, relapsing–remitting multiple sclerosis.
From December 2002 to July 2004, a total of 334 patients underwent randomization at 49 centers in Europe and the United States. The last patient started treatment in September 2004. Essay! Each patient provided written informed consent. Eligibility criteria were a diagnosis of about modern technology essay relapsing–remitting multiple sclerosis (on the basis of the McDonald criteria 5 ) with an onset of symptoms no more than 36 months before the time of screening; at least two clinical episodes during the previous 2 years; a score of 3 or less on shoe essay conclusion, the Expanded Disability Status Scale (EDSS), 6 which ranges from modern technology essay 0 to 10, with higher scores indicating greater disability; and one or more enhancing lesions, as seen on essay harry stone, at least one of up to four monthly cranial magnetic resonance imaging (MRI) scans. Key exclusion criteria were previous disease-modifying treatments, a history of clinically significant autoimmunity, or the presence of serum antithyrotropin-receptor antibodies. Eligible patients were randomly assigned in a 1:1:1 ratio to receive alemtuzumab (at a dose of about modern technology essay either 12 mg per day or 24 mg per democracy and media essay day) or interferon beta-1a with the use of the Pocock and Simon minimization algorithm 7 to balance the study groups with regard to age (30 years or ?30 years), sex, and baseline EDSS score (2.0 or ?2.0). Alemtuzumab was given by intravenous infusion on 5 consecutive days during the first month and on 3 consecutive days at months 12 and 24 (the latter at the treating physicians' discretion if the CD4+ T-cell count was ?100?10 6 cells per liter). Interferon beta-1a (at a dose of 44 ?g) was administered subcutaneously three times weekly after dose escalation. All patients received 1 g of intravenous methylprednisolone for 3 days at baseline and at months 12 and 24, coinciding with infusion cycles as premedication for those receiving alemtuzumab.
Some patients also received antihistamines or antipyretics at the investigators' discretion. EDSS scores were determined quarterly in modern essay a blinded fashion by a neurologist who also adjudicated possible relapses. Hass Essay! Patients wore clothing that covered injection sites. The effectiveness of technology essay blinding was assessed at the end-of-study visit. Safety was assessed quarterly by the treating neurologist, who was aware of study-group assignment. The coprimary measures of efficacy were the time to sustained accumulation of disability and the rate of relapse. Disability was assessed according to the ordinal EDSS score.
A sustained accumulation of disability was defined as an increase of at least 1.5 points for patients with a baseline score of 0 and reflective essay on justice, of at least 1.0 point for patients with a baseline score of modern essay 1.0 or more; all scores were confirmed twice during a 6-month period. The onset of a sustained level of disability was timed to the first recorded increase in the EDSS score aside from relapse. Hass Images! Patients with an increased level of disability could be discontinued from the study. A relapse was defined as new or worsening symptoms with an objective change in neurologic examination attributable to multiple sclerosis that lasted for at least 48 hours, that were present at normal body temperature, and that were preceded by at essay, least 30 days of harry sorcerer stone clinical stability. Secondary outcomes were the proportion of patients who did not have a relapse, changes in lesion burden (as seen on T 2 -weighted MRI), and modern technology essay, brain volume (as measured by atlas shrugged, the Losseff method on technology essay, T 1 -weighted MRI 8 ). MRI scans were performed annually and interpreted by a neuroradiologist at Perceptive Informatics who was unaware of assignments to study groups. Thyroid function and levels of antithyrotropin-receptor antibodies and horn essay conclusion, lymphocyte subpopulations were measured quarterly at about modern, a central laboratory (Cirion Clinical Trial Services and Charles River Laboratories). Serum-binding antibodies against alemtuzumab were measured with the use of a validated enzyme-linked immunosorbent assay (ELISA) 9 at BioAnaLab. There was no active monitoring for progressive multifocal leukoencephalopathy.
Criteria for the diagnosis of immune thrombocytopenia were a single confirmed platelet count of fewer than 50,000 per short microliter without clumping or a platelet count of more than 50,000 but fewer than 100,000 per microliter on at least two consecutive occasions during a period of at least 1 month, with normal hemoglobin, neutrophil, and eosinophil counts; an absence of splenomegaly; and a normal peripheral-blood smear (apart from thrombocytopenia). All adverse events with an about modern essay onset up to 36 months are reported. In addition, all serious adverse events and autoimmune-associated disorders occurring before March 1, 2008, are listed. A subsequent adverse event of Burkitt's lymphoma not associated with Epstein–Barr virus (EBV) is also included in this report. On the basis of the literature, 2-16 we determined that 285 patients would be needed to provide a power of 75% to detect a treatment effect at 36 months, assuming a rate of horn sustained disability of 12% in the alemtuzumab group and of 30% in the group receiving interferon beta-1a with a two-sided test and a significance level of 2% (with a Bonferroni adjustment for two alemtuzumab groups and a significance level of 1% for the comparison of relapse rates).
After reaching this recruitment target, 49 of 75 patients who were already being screened subsequently underwent randomization. Preplanned interim analyses were performed when most patients had completed at about modern technology, least 1 year and 2 years with a prespecified alpha spending function. Stone! Disclosure of these results formed part of about modern technology safety announcements by sonata essay, the sponsor in September 2005 and 2006. After the interim analyses, P values of less than 0.016 and 0.004 were considered to have statistical significance for the rates of sustained disability and about technology essay, relapse, respectively (for details, see the Supplementary Appendix, available with the full text of this article at www.nejm.org). Treatment effects were compared with respect to the time to sustained accumulation of disability with the use of a proportional-hazards model and to hass images the rate of about essay relapse with the use of the Andersen–Gill model with robust variance estimation. 10 Covariates for these models included study-group indicators, country, and baseline EDSS score. The proportion of sonata patients with relapse-free survival was assessed with the use of logistic regression. The estimated percentage of patients with sustained disability or relapse was generated by the Kaplan–Meier method.
The annualized rate of relapse was estimated with the use of Poisson regression. The number of modern patients who would need to be treated with alemtuzumab instead of interferon beta-1a to prevent one patient from having a relapse or sustained disability was calculated according to essay the proportion of patients who did not have these outcomes at month 36. About Essay! 11 Comparisons of EDSS scores were based on a repeated-measures analysis of covariance. A proportional-odds model was used to estimate improvement, stabilization, and on justice, worsening of the about essay EDSS score, as compared with baseline. The percent change from baseline on MRI was analyzed with the use of the Wilcoxon–Mann–Whitney test and the multivariate Wei–Lachin test 12,13 during the entire 36-month period. For the rate of sustained disability, a sensitivity analysis was conducted that limited the short essay required period for modern technology an increased EDSS score to essay 3 months. Fisher's exact test and Poisson regression were used for the analysis of adverse events and event rates, respectively. The reported P values are two-sided and were not adjusted for multiple testing. About Modern! In addition to the comparisons between two alemtuzumab groups and the group receiving interferon beta-1a, comparisons of the sonata pooled alemtuzumab groups and the group receiving interferon beta-1a are reported.
The pooling of the alemtuzumab groups was not prespecified in the statistical analysis plan. The protocol was designed by the lead academic authors and was approved by local review boards or the ethics committee at each center. Technology Essay! Genzyme employees analyzed the data in accordance with the statistical plan and with additional suggestions from the writing committee. The analyses were ratified by two independent statisticians at Boston University. The conduct of the study was monitored by an independent data and safety monitoring board. Essay! The lead academic authors vouch for the completeness and veracity of the data and analyses. Essay! Of 334 patients who underwent randomization, 111 were assigned to receive subcutaneous interferon beta-1a three times weekly, and 223 were assigned to receive annual cycles of reflective alemtuzumab, with 113 receiving 12 mg per day and 110 receiving 24 mg per day.
One patient who received alemtuzumab was included in the safety analysis but was excluded from the efficacy analyses because the initial diagnosis of multiple sclerosis was incorrect, and the patient received the diagnosis of about modern essay cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) during the study. Baseline demographic and clinical characteristics were similar in the three treatment groups ( Table 1 Table 1 Baseline Characteristics of the Patients. Shoe Sonata Essay Conclusion! ). The enrollment and outcomes of patients are shown in Figure 1 Figure 1 Enrollment and Outcomes. . The absence of an enhancing lesion on initial MRI scans was the commonest cause of about modern technology essay screening failure. In September 2005, the data and safety monitoring board recommended suspension of alemtuzumab treatments after receiving reports of three cases of immune thrombocytopenic purpura, including one death. All safety and efficacy assessments proceeded as planned, and short, patients who were receiving interferon beta-1a continued to receive the drug. At the time of dose suspension, only about modern 2 eligible patients (1%) had not received the second cycle of alemtuzumab at robert hass, month 12, whereas 155 patients (75%) were precluded from about receiving the third cycle of alemtuzumab at month 24. We implemented a program to ensure prompt identification and atlas contest, appropriate management of immune thrombocytopenic purpura. This program included education for patients and physicians, monthly blood counts, and regular contact with patients, which included discussion about symptoms and signs of immune thrombocytopenic purpura.
Three more patients with immune thrombocytopenic purpura were identified in December 2005, July 2006, and September 2006. Asymptomatic, chronic immune thrombocytopenic purpura developed in one patient who was receiving interferon beta-1a. More patients discontinued interferon beta-1a than alemtuzumab, principally because of a lack of about efficacy and adverse events, so that only 59% of the original group of patients receiving interferon beta-1a completed the 36-month study, as compared with 83% of patients receiving alemtuzumab. Contest! At the end of the study review, 90% and essay, 91% of raters remained unaware of assignments to the group receiving interferon beta-1a and the group receiving alemtuzumab, respectively. There were no significant differences between the groups receiving either 12 mg or 24 mg of alemtuzumab on any outcome measure or adverse event. Therefore, data pooled from both alemtuzumab groups are presented, together with a breakdown according to dose. Short On Computer! As compared with interferon beta-1a, alemtuzumab reduced the risk of sustained disability by 71% (hazard ratio, 0.29; 95% confidence interval [CI], 0.16 to modern technology 0.54; P0. 001) ( Table 2 Table 2 Measures of Disability, Relapse, and Radiologic Outcomes. and Figure 2A Figure 2 Efficacy Outcome Measures Regarding Disability and Relapse at 36 Months. Panel A shows Kaplan–Meier curves for patients who reached the criteria for sustained accumulation of disability. Panel B shows the horn essay conclusion cumulative number of relapses. Panel C shows the estimated mean score on the Expanded Disability Status Scale (EDSS, which ranges from 0 to 10, with higher scores indicating greater disability) on the basis of repeated-measures analysis of covariance.
The vertical lines represent 95% confidence intervals. About Modern Technology Essay! Panel D shows the annualized relapse rate from baseline to 36 months for 222 patients who received alemtuzumab and democracy and media, from month 24 to month 36 for 97 patients who received alemtuzumab for about modern essay two cycles and 45 patients who received alemtuzumab for democracy three cycles. Also shown are annualized rates of relapse from baseline to month 36 for 111 patients who received interferon beta-1a and from month 24 to modern month 36 for 74 patients who received interferon beta-1a. The annualized relapse rates were estimated with the essay images use of Poisson regression analysis separately for modern technology essay patients who received a third cycle of therapy and for those who did not receive a third cycle. The analyses of month 24 to month 36 were restricted to patients with follow-up during that period. The vertical lines represent standard errors. ). For the 12-mg dose, the risk of sustained disability was reduced by 75% (hazard ratio, 0.25; 95% CI, 0.11 to 0.57; P0.001); for the 24-mg dose, the risk reduction was 67% (hazard ratio, 0.33; 95% CI, 0.16 to 0.69; P=0.003). The number of simple short essay on computer patients who would need to be treated with alemtuzumab instead of interferon beta-1a to avoid one sustained disability event during the 36-month period was 5.8 (5.6 for the 12-mg dose and 6.0 for the 24-mg dose).
In sensitivity analysis of the risk of sustained disability at 3 months, the risk reduction was 64% (hazard ratio, 0.36; 95% CI, 0.21 to 0.60; P0.001). Technology Essay! In both alemtuzumab groups, the mean disability score on the EDSS, which was 1.9 points at baseline, improved by 0.39 point (95% CI, 0.23 to 0.55) at 36 months: 0.32 point for the 12-mg dose (P=0.006) and atlas essay 2012, 0.45 point for the 24-mg dose (P=0.001). During the same time, the mean disability score worsened by 0.38 point (95% CI, 0.13 to 0.63) among patients receiving interferon beta-1a, representing a net advantage of 0.77 point (95% CI, 0.48 to 1.06; P0.001) among patients receiving alemtuzumab ( Table 2 and Figure 2C ). As compared with interferon beta-1a, the modern essay estimated odds ratio for worsening disability versus either improved or stable disability was 0.41 (95% CI, 0.24 to 0.69) for the 12-mg dose of sonata conclusion alemtuzumab and 0.33 (95% CI, 0.19 to 0.56) for the 24-mg dose (P0.001 for both comparisons). As compared with interferon beta-1a, alemtuzumab reduced the rate of relapse by 74% (hazard ratio, 0.26; 95% CI, 0.16 to 0.41; P0. 001) ( Table 2 and Figure 2B ); both alemtuzumab doses were effective, with a reduction of modern technology 69% (95% CI, 48 to 82) for the 12-mg dose and 79% (95% CI, 60 to shrugged 2012 89) for the 24-mg dose (P0.001 for both comparisons).
The annualized relapse rate at 36 months was 0.36 for interferon beta-1a and 0.10 for alemtuzumab (0.11 for technology the 12-mg dose and 0.08 for the 24-mg dose). The proportion of patients who remained relapse-free at 36 months was 52% for interferon beta-1a and 80% for alemtuzumab (77% for essay the 12-mg dose and 84% for the 24-mg dose; P0.001 for both comparisons) ( Table 2 ). The number of patients who would need to be treated with alemtuzumab instead of interferon beta-1a to prevent 1 patient from having a relapse at 36 months was 3.5 (3.9 and 3.1 for the 12-mg dose and 24-mg dose, respectively). There were no significant differences in safety or treatment effect on essay, disability between patients receiving two cycles of alemtuzumab and those receiving three cycles of the drug. However, there was evidence of the waning of treatment efficacy on horn sonata essay conclusion, the rate of relapse. The annualized rate of relapse in 161 patients who received two cycles of about alemtuzumab was 0.16 in months 24 to 36, an potter increase from 0.07 for months 0 to about modern essay 12 and 0.06 for months 12 to 24. This rate was significantly reduced, as compared with the robert rate of 0.34 in patients receiving interferon beta-1a between months 24 and 36 (P=0.01). Technology Essay! Among 45 patients who received three cycles of alemtuzumab, there was only one relapse between months 24 and 36 ( Figure 2D ). From baseline to 36 months, there was a reduction in the volume of lesions, as seen on T 2 -weighted MRI, in democracy essay all three study groups ( Table 2 ). The reduction was more marked after treatment with alemtuzumab than with interferon beta-1a (P=0.005), with significant reductions from baseline at about modern technology, months 12 (P=0.01) and 24 (P=0.005). The differences in median change at month 36 were not significant.
Of note, the sample size for the 36-month analyses was reduced because of the number of patients who discontinued the study and simple short essay, the 26 patients who had missing or technically deficient MRI scans. The reduction in technology brain volume between baseline and month 36 was significantly less among patients receiving alemtuzumab than among those receiving interferon beta-1a (?0.5% and ?1.8%, respectively; P=0.05). Recognizing that atrophy measures may be confounded by early suppression of shrugged inflammatory space-occupying lesions, we analyzed brain volume between months 12 and 36; this measure was reduced by 0.2% among patients receiving interferon beta-1a but was increased by 0.9% in those receiving alemtuzumab (P=0.02) ( Table 2 ). Modern Essay! On clinical and MRI outcomes, alemtuzumab remained superior to interferon beta-1a after subgroup analyses according to study-site location, baseline EDSS score, lesion load on T 2 -weighted MRI, cerebral volume on T 1 -weighted MRI, sex, race, and age of patients (data not shown). Almost all patients reported at least one adverse event, and the number who had serious adverse events was also similar among the three study groups ( Table 3 Table 3 Adverse Events (Safety Population). and the Supplementary Appendix). There were two deaths, both in the alemtuzumab group. One patient who had several preexisting cardiac risk factors died of cardiovascular disease. The other death was attributable to immune thrombocytopenic purpura.
Three cancers (non–EBV-associated Burkitt's lymphoma, breast cancer, and cervical cancer in situ) were reported in patients in harry potter sorcerer stone the alemtuzumab group, with onset ranging from 22 to 64 months after the first annual cycle; among patients receiving interferon beta-1a, one case of colon cancer was reported at 36 months ( Table 3 ). Serious infusion reactions occurred in three patients (1.4%) in the alemtuzumab group and led to discontinuation in one patient (0.5%). Technology Essay! Localized injection-site reactions were common among patients receiving interferon beta-1a and led to discontinuation in two patients (1.9%). Abnormal liver-function tests were seen in 2.3% of patients in the alemtuzumab group and in 15.0% of those receiving interferon beta-1a, causing discontinuation of interferon beta-1a in three patients and grade 4 hepatic failure in one patient. Mild-to-moderate infections, especially of the respiratory tract, were more common among patients in the alemtuzumab group than in shrugged those receiving interferon beta-1a. Recurrent oral herpes simplex virus type 1 was seen in three patients immediately after each cycle of alemtuzumab. Inactive tuberculosis was identified incidentally in one patient receiving the 24-mg dose of alemtuzumab. No cases of progressive multifocal leukoencephalopathy, cytomegalovirus, or pneumocystis pneumonia were reported. Immune thrombocytopenic purpura developed in six patients (2.8%) receiving alemtuzumab and one patient (0.9%) receiving interferon beta-1a (P=0.43). The index patient suffered a fatal brain hemorrhage before diagnosis. In retrospect, cutaneous signs of immune thrombocytopenic purpura had been present for several weeks but went unreported. Of the six patients receiving alemtuzumab in whom immune thrombocytopenic purpura developed, four were receiving the 24-mg dose (three patients after two cycles and one after three) and two were receiving the 12-mg dose (both after three cycles).
Remission of immune thrombocytopenic purpura occurred without treatment in one patient, after corticosteroid therapy in two patients, and after rituximab therapy in two patients. Grade 2 thrombocytopenia developed in one patient after 3 months of receiving interferon beta-1a; the condition persisted despite the about modern essay withdrawal of interferon beta-1a and remained at grade 1 at harry sorcerer, the end of the study after reintroduction of interferon beta-1a. Technology Essay! Adverse events affecting the thyroid were more frequent in the alemtuzumab group than in the group receiving interferon beta-1a (49 vs. 3) ( Table 3 ); these events were associated with thyroid autoantibodies in 96% of affected patients and occurred up to 30 months after the last dose of a study drug. Three patients (1.4%) in the alemtuzumab group had serious hyperthyroid events, and sonata conclusion, 32 patients had hyperthyroidism, including 25 with sustained hyperthyroidism. Others had transient hyperthyroidism followed by normalization (four patients), sustained hypothyroidism (six), or hypothyroidism followed by about, hyperthyroidism (two). Four patients underwent thyroid ablation with radioactive iodine, and 24 were treated with antithyroid agents (3 only temporarily).
Primary hypothyroidism developed in 10 patients. In total, 18 patients required long-term thyroid-replacement therapy. Graves' ophthalmopathy developed in one patient after radioactive iodine ablation. Essay On Justice! (Numbers of patients were derived from in-depth case analyses and may differ from numbers of adverse events reported by investigators, as listed in modern essay Table 3 .) Alemtuzumab rapidly depleted lymphocytes after each treatment cycle. Lymphocyte reconstitution was similar for both doses. B-cell numbers returned to normal between 3 and 6 months. T-cell counts rose slowly and remained subnormal for the duration of the study; the median time for recovery of CD4+ lymphocytes was 3 months for 100?10 6 cells per liter; the time ranged from harry potter 6 to 9 months for 200?10 6 cells per liter. Alemtuzumab-binding antibodies above the prespecified threshold of 2000 U per milliliter were detected in 1 of 208 patients (0.5%) and 51 of 194 patients (26.3%) at 12 and 24 months, respectively. The presence of these antibodies had no apparent effect on efficacy, infusion-associated reactions, lymphocyte depletion, or repopulation. Among previously untreated patients with early, relapsing–remitting multiple sclerosis, alemtuzumab reduced the risk of sustained accumulation of disability by 71% and the risk of about essay relapse by 74% (P0.001 for both), as compared with interferon beta-1a.
Efficacy was maintained over 36 months, even though 72% of alemtuzumab-treated patients did not receive the planned third cycle of therapy at month 24 because of safety concerns. The reduction in the lesion load on sonata conclusion, T 2 -weighted MRI was greater among patients receiving alemtuzumab than among those receiving interferon beta-1a, although the difference at 36 months was not significant; comparisons were limited by missing MRI data and the high discontinuation rate for about modern essay interferon beta-1a. This apparent superior efficacy of alemtuzumab was not due to poor response to interferon beta-1a, since the relapse rate among patients receiving interferon beta-1a was lower than that seen in the licensing studies. 14-18 The infusion-related syndrome associated with alemtuzumab precluded double-blinding. 19 Therefore, we used a rater who was unaware of treatment assignments for efficacy outcomes, as advocated by essay on computer, the American Academy of Neurology, 20 and confirmed successful maintenance of blinding throughout the study. Although our study suggests that alemtuzumab is more effective than interferon beta-1a when given at the earliest stages of relapsing–remitting multiple sclerosis, our findings raise the difficult issue of exposing young adults who have little disability to a drug having potentially serious adverse effects. Our phase 2 trial was not designed to assess the long-term safety of alemtuzumab, nor was it powered to detect uncommon adverse events. However, the about technology essay trial was larger and longer than other recent phase 2 trials 21,22 and, unlike them, used an active licensed comparator. Shoe! To date, the major safety concern is autoimmunity, already known to about essay be a generic complication of immune reconstitution from lymphocytopenia. 23,24 Thyroid autoimmunity was observed, as reported previously.
4. Immune thrombocytopenic purpura caused the death of atlas essay contest one patient. After the about technology essay report of two further cases, the data and safety monitoring board suspended the administration of alemtuzumab between September 2005 and May 2007. Risk minimization measures effectively identified subsequent patients with immune thrombocytopenic purpura, and such measures should be considered mandatory for the safe future use of alemtuzumab. Immune thrombocytopenic purpura was seen in horn conclusion 2.8% of patients receiving alemtuzumab and about essay, 0.9% of those receiving interferon beta-1a. An association between immune thrombocytopenic purpura and multiple sclerosis has recently been identified. 25-28 Immune thrombocytopenic purpura has also been reported after the shoe horn sonata essay administration of alemtuzumab in the context of hematopoietic stem-cell transplantation and for other conditions. 29-31 There is insufficient information to draw conclusions regarding the technology essay risk of cancer associated with alemtuzumab in this population, since cancer was diagnosed in three patients in shoe sonata the alemtuzumab group and one patient receiving interferon beta-1a. Mean disability scores improved among patients in the alemtuzumab group, as first seen in our open-label study of technology essay alemtuzumab, 2 but worsened among those receiving interferon beta-1a.
If improvements in disability after alemtuzumab are sustained, there would be important implications for the management of multiple sclerosis. Short Essay On Computer! An improvement of 0.39 EDSS point from a baseline score of 2.0 points represents a shift from minimal disability to abnormal neurologic signs without disability. This clinical change was matched by about, an increase in brain volume on democracy, T 1 -weighted MRI between months 12 and 36, whereas brain atrophy advanced among patients receiving interferon beta-1a. A possible mechanism may be the secretion of neurotrophins by technology, lymphocytes that are regenerated after the administration of alemtuzumab. 32 Together, these findings support the hypothesis that early suppression of atlas shrugged essay contest 2012 inflammation in multiple sclerosis inhibits the complex cascade of disease mechanisms responsible for long-term disability. Supported by Genzyme and Bayer Schering Pharma. About Modern Technology Essay! Dr. Coles reports receiving consulting and lecture fees and hass, grant support from Genzyme; Dr. Compston, receiving consulting and lecture fees and grant support from Genzyme and about, lecture fees from Bayer Schering Pharma; Dr. Selmaj, receiving consulting fees from Genzyme, Biogen Idec, and Biopartners and lecture fees from Schering, Novartis, and Biogen Idec; and essay, Drs. Lake, Moran, Margolin, and Tandon and Ms.
Norris, being employees of Genzyme and having an equity interest in the company. No other potential conflict of interest relevant to about modern essay this article was reported. The members of the writing group (Alasdair J. Coles, Ph.D., F.R.C.P., and D. Alastair S. Compston, F.Med.Sci., Ph.D., University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Krzysztof W. Atlas Shrugged Essay 2012! Selmaj, M.D., Ph.D., Department of Neurology, Medical University of Lodz, Lodz, Poland; and Stephen L. Modern Essay! Lake, Sc.D., Susan Moran, M.D., M.S.C.E., David H. Margolin, M.D., Ph.D., Kim Norris, B.Sc., and P.K. Tandon, Ph.D., Genzyme, Cambridge, MA) assume responsibility for the overall content and atlas, integrity of the article. We thank the about modern following Genzyme employees for their assistance in study operations and data analysis: D. Essay Sorcerer! Boisvert, R. Modern! Clark, R. Dhanjal, J. Haas, O. Haider, A. Feleaga, K. Hoffman, G. Newgard, T. Reflective Essay! Rios, M. Rizzo, and Q. Yu. Address reprint requests to Drs. Coles and Compston at the Department of Neurology, Box 165, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom, or at about modern technology essay, email@example.com or firstname.lastname@example.org. Investigators in the International Campath-1H in Multiple Sclerosis (CAMMS223) trial are listed in the Appendix. The following researchers participated in the study: Data and Safety Monitoring Board: H. Panitch (chair), University of Vermont, Burlington; E. And Media! Anaissie, University of Arkansas for Medical Sciences, Little Rock; D. Cines, University of Pennsylvania, Philadelphia; L. DeGroot, Brown University, Providence, RI; F. Technology Essay! Dorsey, Franklin, ME; T. Atlas Essay! Phillips, Texas Neurology, Dallas; J. About Essay! Simon, Portland Veterans Affairs Medical Center, Portland, OR. Sonata! Investigators and Study Centers: Croatia: V. Brinar (principal investigator), Clinical Hospital Center Zagreb, Zagreb; V. Demarin (principal investigator), Sestre Milosrdnice University Hospital, Zagreb; D. Modern Essay! Janculjak (principal investigator), Clinical Hospital Osijek, Osijek; J. Short On Computer! Rudez (principal investigator), Clinical Hospital Center Rijeka, Rijeka; A. Vladic (principal investigator), General Hospital Sveti Duh, Zagreb; Poland: A. Czlonkowska (principal investigator), D. Modern Technology! Mirowska-Guzel, Institute of Psychiatry and Neurology, Warsaw; W. Kozubski (principal investigator), Medical Academy (Poznan), Poznan; H. Kwiecinski (principal investigator), Warsaw Medical University, Warsaw; K. Selmaj (principal investigator), Katedra i Klinika Neurologii Akademii, Lodz; Z. Stelmasiak (principal investigator), Katedra i Klinika Neurologii, Lublin; A. Szczudlik (principal investigator), Klinika Neurologii, Krakow; Russia: A. Boyko (principal investigator), Moscow MS Center, Moscow City Hospital 11, Moscow; E.I.
Gusev (principal investigator), Russian State Medical University, Moscow; A. Essay Images! Skoromets (principal investigator), St. Petersburg State Pavlov Medical, St. Petersburg; I. Stolyarov (principal investigator), Institute of the Human Brain, St. Modern Technology! Petersburg; N. Shoe Horn Sonata! Yakhno (principal investigator), Moscow City Hospital 61, Moscow; I. Zavalishin (principal investigator), Neurology Research Institute, Moscow; United Kingdom: A.J. About Technology Essay! Coles (principal investigator), D.A.S. Compston (principal investigator), J. Democracy And Media Essay! Shawcross, J. Jones, A.L.
Cox, Addenbrooke's Hospital, Cambridge; United States: A. About Modern Essay! Bass (principal investigator), D. Wenzel, Neurology Center of San Antonio, San Antonio, TX; V. Biton (principal investigator), Clinical Trials, Little Rock, AR; M. Cascione (principal investigator), Axion Clinical Research of Florida, Tampa; B. Cleeremans (principal investigator), NervePro Research, Irvine, CA; J. Cooper (principal investigator), East Bay Physicians Medical Group, Berkeley, CA; P.K. Coyle (principal investigator), D. Madigan, SUNY at Stony Brook, Stony Brook, NY; B. Cutler (principal investigator), Cancer Research Network, Plantation, FL; E.J. Fox (principal investigator), L. Mayer, R. Tyer, Central Texas Neurology Consultants, Round Rock; S. Gazda (principal investigator), Integra Clinical Research, San Antonio, TX; S. Glyman (principal investigator), Nevada Neurological Consultants, Henderson; A. Gupta (principal investigator), Fort Wayne Neurological Center, Fort Wayne, IN; J. Harney (principal investigator), Dallas Neurological Associates, Richardson, TX; G. Contest! Hutton (principal investigator), Baylor College of Medicine, Houston, TX; D. Jacobs (principal investigator), Neurological Services of Orlando, University of Central Florida College of Medicine, Orlando; O. Khan (principal investigator), R. Lisak, A. Tselis, Wayne State University School of Medicine, Detroit; J. Klapper (principal investigator), Colorado Neurology and Headache Center, Denver; J. Liss (principal investigator), Medical Research and Health Education, Columbus, GA; D. Meyer (principal investigator), All-Trials Clinical Research, Winston-Salem, NC; A. Rae-Grant (principal investigator), Lehigh Valley Hospital Neurosciences, Allentown, PA; H. Rossman (principal investigator), W. Boudouris, M. Belkin, R. About Technology Essay! Pierce, Michigan Institute for Neurological Disorders, Farmington; W. Royal (principal investigator), University of Maryland, Baltimore; R. And Media! Shubin (principal investigator), D. Sider, Neuro-Therapeutics, Pasadena, CA; M. Stein (principal investigator), MS Service, Walnut Creek, CA; B. Modern Essay! Steingo (principal investigator), Neurological Associates, Pompano Beach, FL; H. Sullivan (principal investigator), Michigan Medical, Grand Rapids; C. Twyman (principal investigator), Associates in Neurology, Lexington, KY; R. Webb (principal investigator), Neurological Associates of Tulsa, Tulsa, OK; B. Weinshenker (principal investigator), B.M. Keegan, D. Democracy Essay! Rauchwarter, Mayo Clinic, Rochester, MN; D. About Essay! Wingerchuk (principal investigator), J. Carter, Mayo Clinic Arizona, Scottsdale; S. Wray (principal investigator), Knoxville, TN; D. Wynn (principal investigator), N. Allen, C. Nagar, D. O'Brien, Consultants in Neurology, Northbrook IL. MRI Central Reading Center: J. Paskavitz, Perceptive Informatics, Waltham, MA; P. Schaefer, Massachusetts General Hospital, Boston. Reflective! Thyroid Advisory Panel: L. About! DeGroot, Brown University, Providence RI; W. Valente, University of Maryland School of Medicine, Baltimore. Immune Thrombocytopenic Purpura Advisory Panel: D. Beardsley, Yale University School of Medicine, New Haven, CT; J. Bussel, Weill Cornell Medical College of Cornell University, New York; D. Cines, University of robert Pennsylvania, Philadelphia; M. Goldberg, Genzyme, Cambridge, MA; R. MacMillan, Scripps Cancer Center, La Jolla, CA; D. Scadden, Massachusetts General Hospital, Boston. Independent Statisticians: R.B. D'Agostino, M. Pencina, Boston University, Boston. Study Manager: G. Gonzales, Genzyme.
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Laure Michel, Catherine Larochelle, Alexandre Prat. . (2015) Update on treatments in multiple sclerosis. La Presse Medicale 44 :4, e137. Mu Yang, Corentin Peyret, Xiang Qun Shi, Nicolas Siron, Jeong Ho Jang, Sonia Wu, Sylvie Fournier, Ji Zhang. . (2015) Evidence from Human and Animal Studies: Pathological Roles of images CD8+ T Cells in Autoimmune Peripheral Neuropathies. Frontiers in Immunology 6 . Hans-Peter Hartung, Orhan Aktas, Alexey N Boyko. . (2015) Alemtuzumab: A new therapy for active relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal 21 :1, 22-34. Eva Havrdova, Dana Horakova, Ivana Kovarova. Modern Essay! . (2015) Alemtuzumab in the treatment of multiple sclerosis: key clinical trial results and considerations for use. Therapeutic Advances in Neurological Disorders 8 :1, 31-45.
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Joanne L. Jones, Alasdair J. Coles. . Shoe Sonata Conclusion! (2014) Mode of action and clinical studies with alemtuzumab. Experimental Neurology 262 , 37-43. Sandra Meyer-Moock, You-Shan Feng, Mathias Maeurer, Franz-Werner Dippel, Thomas Kohlmann. . (2014) Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis. BMC Neurology 14 :1. Simon A. Technology Essay! Broadley, Michael H. Barnett, Mike Boggild, Bruce J. Brew, Helmut Butzkueven, Robert Heard, Suzanne Hodgkinson, Allan G. Kermode, Jeannette Lechner-Scott, Richard A.L. Macdonell, Mark Marriott, Deborah F. Mason, John Parratt, Stephen W. Reddel, Cameron P. Shaw, Mark Slee, Judith Spies, Bruce V. Taylor, William M. Carroll, Trevor J. Kilpatrick, John King, Pamela A. McCombe, John D. Pollard, Ernest Willoughby. . Harry! (2014) Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 2 New and emerging therapies and technology, their efficacy. Journal of Clinical Neuroscience 21 , 1847-1856. Rehana Z. Hussain, Liat Hayardeny, Petra C. Robert! Cravens, Felix Yarovinsky, Todd N. Eagar, Benjamine Arellano, Krystin Deason, Cyd Castro-Rojas, Olaf Stuve. . (2014) Immune surveillance of the central nervous system in multiple sclerosis — Relevance for therapy and experimental models. Journal of Neuroimmunology 276 , 9-17. Xi Xu, Shusong Zhang, Rong Jin, Ke Wang, Pingping Li, Liang Lin, Jie Dong, Jie Hao, Yan Zhang, Xiuyuan Sun, Xuewen Pang, Xiaoping Qian, Jun Zhang, Hounan Wu, Yu Zhang, Qing Ge. . (2014) Retention and tolerance of autoreactive CD4+ recent thymic emigrants in the liver.
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C. M. Rice. Technology! . (2014) Disease modification in multiple sclerosis: an update. Practical Neurology 14 , 6-13. Nicola Stefano, Laura Airas, Nikolaos Grigoriadis, Heinrich P. Sonata! Mattle, Jonathan O’Riordan, Celia Oreja-Guevara, Finn Sellebjerg, Bruno Stankoff, Agata Walczak, Heinz Wiendl, Bernd C. Kieseier. . (2014) Clinical Relevance of Brain Volume Measures in Multiple Sclerosis. CNS Drugs . Paul W. O’Connor, Jiwon Oh. . 2014. Disease-modifying agents in multiple sclerosis. Multiple Sclerosis and about modern essay, Related Disorders, 465-501. Lucienne Chatenoud. . 2014. Treatment of shoe sonata essay conclusion Autoimmune Disease. The Autoimmune Diseases, 1221-1245. H. Waldmann. . 2014.
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Brian A Baldo. . Modern Technology Essay! (2013) Adverse events to monoclonal antibodies used for shrugged 2012 cancer therapy: Focus on technology essay, hypersensitivity responses. OncoImmunology 2 , e26333. G. Edan. . (2013) L’IRM est-elle utile dans le suivi des patients atteints de sclerose en plaques ? Non. Revue Neurologique . Amir-Hadi Maghzi, Alireza Minagar, Emmanuelle Waubant. . (2013) Neuroprotection in Multiple Sclerosis: A Therapeutic Approach. CNS Drugs 27 , 799-815. Jeffrey A. Simple Short Essay! Cohen. . (2013) Mesenchymal stem cell transplantation in multiple sclerosis. Journal of the Neurological Sciences 333 , 43-49. Technology Essay! Iris Mair, Ben C Reynolds, Stephen M Anderton. Shoe Sonata Essay! . Modern Essay! 2013. Immunological Tolerance: Therapeutic Induction. eLS. Francesco Torino, Agnese Barnabei, Rosamaria Paragliola, Roberto Baldelli, Marialuisa Appetecchia, Salvatore Maria Corsello. . (2013) Thyroid Dysfunction as an Unintended Side Effect of Anticancer Drugs.
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Expert Opinion on democracy, Therapeutic Targets 17 , 1053-1066. Jennifer Graves, Steven L Galetta, Jeffrey Palmer, David H Margolin, Marco Rizzo, John Bilbruck, Laura J Balcer. . About Modern! (2013) Alemtuzumab improves contrast sensitivity in patients with relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal 19 :10, 1302-1309. L. Klotz, S.G. Meuth, B. Kieseier, H. Wiendl. . (2013) Alemtuzumab bei schubformig-remittierender multipler Sklerose. Der Nervenarzt 84 , 984-994. Shrugged Contest! Matthew McCoyd. . (2013) Update on Therapeutic Options for Multiple Sclerosis.
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Aaron Martin, Roland M. Tisch, Daniel R. Getts. . (2013) Manipulating T cell-mediated pathology: Targets and atlas shrugged contest, functions of monoclonal antibody immunotherapy. Clinical Immunology 148 , 136-147. Carlo Pozzilli, Luca Prosperini. About Technology! . 2013. Head-to-head versus therapy-change studies. Personalized Management of Multiple Sclerosis, 108-122. Thomas Williams, Alasdair Coles, Laura Azzopardi. Essay Images! . (2013) The Outlook for Alemtuzumab in Multiple Sclerosis. BioDrugs 27 , 181-189. Gilles Edan, Emmanuelle Page. . (2013) Induction Therapy for about essay Patients with Multiple Sclerosis: Why? When? How?. CNS Drugs 27 , 403-409.
Jeremy M Clain, Rodrigo Cartin-Ceba, Ulrich Specks. . And Media Essay! (2013) Biologic response modifiers for granulomatosis with polyangiitis (Wegener’s): from promise to technology essay reality. International Journal of Clinical Rheumatology 8 , 383-397. R. Depaz, J. Essay Sorcerer Stone! Aboab, O. Gout. About Technology Essay! . (2013) Actualites dans le diagnostic et la prise en charge therapeutique de la sclerose en plaques. La Revue de Medecine Interne . Luisa Klotz, Heinz Wiendl. . (2013) Monoclonal antibodies in neuroinflammatory diseases. Expert Opinion on Biological Therapy 13 , 831-846.
Barry A Singer. . (2013) Fingolimod for atlas essay contest the treatment of relapsing multiple sclerosis. Expert Review of Neurotherapeutics 13 , 589-602. Modern Technology! Esther Bandala-Sanchez, Yuxia Zhang, Simone Reinwald, James A Dromey, Bo-Han Lee, Junyan Qian, Ralph M Bohmer, Leonard C Harrison. . (2013) T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nature Immunology 14 , 741-748. Roger Lee Mendoza. . (2013) Pharmacoeconomics and clinical trials in multiple sclerosis: baseline data from the European Union.
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Brenda Banwell, Gavin Giovannoni, Christopher Hawkes, Fred Lublin. . (2013) Editors' welcome and a working definition for a multiple sclerosis cure. Multiple Sclerosis and Related Disorders 2 , 65-67. Eduardo Nobile-Orazio, Francesca Gallia. . (2013) Multifocal Motor Neuropathy: Current Therapies and Novel Strategies. Drugs 73 , 397-406. Abhijit Chaudhuri, Peter O. Technology! Behan. . (2013) Lessons from clinical trials of shoe horn conclusion alemtuzumab in multiple sclerosis. About Modern Technology! Multiple Sclerosis and Related Disorders 2 , 92-95. Amy A. Gelfand, Jeffrey M. Gelfand, Peter J. Goadsby. Robert Hass Essay Images! . Technology! (2013) Migraine and multiple sclerosis: Epidemiology and approach to treatment.
Multiple Sclerosis and Related Disorders 2 , 73-79. Dimitrios Karussis. . (2013) Immunotherapy of Multiple Sclerosis. BioDrugs 27 , 113-148. Gina Remington, Yolanda Rodriguez, Diana Logan, Caroline Williamson, Katherine Treadaway. . (2013) Facilitating Medication Adherence in Patients with Multiple Sclerosis. International Journal of MS Care 15 , 36-45. B. Casanova Estruch. . (2013) Perfil de seguridad y aspectos practicos a tener en cuenta en la administracion de anticuerpos monoclonales. Neurologia 28 :3, 169-178.
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Mediators of Inflammation 2013 , 1-11. Teya M. Tietje, Douglas R. Allington, Michael P. Rivey. On Justice! . (2013) Alemtuzumab: A Place in Therapy for Treatment of Multiple Sclerosis. International Journal of about modern essay Clinical Medicine 04 :10, 459-471. Marinos C. Essay Harry Stone! Dalakas. . (2012) Biologics and about technology, other novel approaches as new therapeutic options in myasthenia gravis: a view to the future. Annals of the New York Academy of Sciences 1274 :10.1111/nyas.2012.1274.issue-1, 1-8. Katherine Buzzard, Simon Broadley, Helmut Butzkueven. . (2012) What Do Effective Treatments for Multiple Sclerosis Tell Us about the Molecular Mechanisms Involved in Pathogenesis?. Simple Short! International Journal of Molecular Sciences 13 , 12665-12709. Nikos Evangelou. Modern Essay! . (2012) The only way to manage neurodegeneration in MS is to prevent it with effective anti-inflammatory therapy: Yes. Multiple Sclerosis Journal 18 :12, 1680-1681.
Alastair Wilkins. . (2012) The only way to manage neurodegeneration in MS is to prevent it with effective anti-inflammatory therapy: No. Multiple Sclerosis Journal 18 :12, 1682-1683. Daniel Ontaneda, Daniela Di Capua. . (2012) Benefits versus risks of essay harry stone latest therapies in multiple sclerosis: a perspective review. Therapeutic Advances in Drug Safety 3 :6, 291-303. Jeffrey A Cohen, Alasdair J Coles, Douglas L Arnold, Christian Confavreux, Edward J Fox, Hans-Peter Hartung, Eva Havrdova, Krzysztof W Selmaj, Howard L Weiner, Elizabeth Fisher, Vesna V Brinar, Gavin Giovannoni, Miroslav Stojanovic, Bella I Ertik, Stephen L Lake, David H Margolin, Michael A Panzara, D Alastair S Compston. . (2012) Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. The Lancet 380 , 1819-1828. Till Sprenger, Ludwig Kappos. . (2012) Alemtuzumab for multiple sclerosis: who and about modern, when to treat?. The Lancet 380 , 1795-1797. Alasdair J Coles, Cary L Twyman, Douglas L Arnold, Jeffrey A Cohen, Christian Confavreux, Edward J Fox, Hans-Peter Hartung, Eva Havrdova, Krzysztof W Selmaj, Howard L Weiner, Tamara Miller, Elizabeth Fisher, Rupert Sandbrink, Stephen L Lake, David H Margolin, Pedro Oyuela, Michael A Panzara, D Alastair S Compston. . (2012) Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial.
The Lancet 380 , 1829-1839. L Midaglia, M Rodriguez Ruiz, D Munoz-Garcia. . (2012) Severe haematological complications during treatment with natalizumab. Multiple Sclerosis Journal 18 :11, 1644-1646. Markus Krumbholz, Tobias Derfuss, Reinhard Hohlfeld, Edgar Meinl. . (2012) B cells and antibodies in hass multiple sclerosis pathogenesis and therapy. Nature Reviews Neurology 8 , 613-623. About Modern Technology Essay! Alessandro Finkelsztejn, Alberto Alain Gabbai, Yara Dadalti Fragoso, Adriana Carra, Miguel Angel Macias-Islas, Raul Arcega-Revilla, Juan Garcia-Bonitto, Carlos Luis Oehninger-Gatti, Geraldine Orozco-Escobar, Adriana Tarulla, Fernando Vergara, Darwin Vizcarra, , , , , , . . (2012) Latin American algorithm for treatment of democracy relapsing-remitting multiple sclerosis using disease-modifying agents. Arquivos de Neuro-Psiquiatria 70 :10, 799-806. About Modern Technology Essay! G Ingram, S Hakobyan, CL Hirst, CL Harris, S Loveless, JP Mitchell, TP Pickersgill, NP Robertson, BP Morgan. . (2012) Systemic complement profiling in multiple sclerosis as a biomarker of disease state.
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Claire L. Helliwell, Alasdair J. Essay! Coles. . (2009) Monoclonal antibodies in multiple sclerosis treatment: current and future steps. Therapeutic Advances in about modern technology Neurological Disorders 2 :4, 195-203. Terri M. Laufer, Gregory F. Hass Images! Wu. . (2009) Treating MS: getting to know the two birds in the bush. Journal of Clinical Investigation . Joanne L. Jones, Chia-Ling Phuah, Amanda L. Cox, Sara A. Thompson, Maria Ban, Jacqueline Shawcross, Amie Walton, Stephen J. Sawcer, Alastair Compston, Alasdair J. Coles. About Modern! . (2009) IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). Hass Essay! Journal of Clinical Investigation . About Modern Technology Essay! M. C. Dalakas, G. Rakocevic, J. Schmidt, M. Horn Sonata! Salajegheh, B. McElroy, M. Modern! O. Harris-Love, J. Reflective Essay On Justice! A. Shrader, E. W. Levy, J. Dambrosia, R. L. Kampen, D. A. Bruno, A. D. About Modern Technology! Kirk. . (2009) Effect of Alemtuzumab (CAMPATH 1-H) in horn sonata conclusion patients with inclusion-body myositis. Modern Technology! Brain 132 , 1536-1544.
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Current Opinion in Neurology 22 , 201-206. Bert A. ‘t Hart, Rogier Q. Hintzen, Jon D. Laman. . (2009) Multiple sclerosis – a response-to-damage model. Trends in Molecular Medicine 15 :6, 235-244. About Modern Technology Essay! Krupa Pandey, Fred D. Lublin. . (2009) Clinically isolated syndrome and multiple sclerosis: Rethinking the arsenal. Current Treatment Options in Neurology 11 , 193-202. John W. Rose, John F. Foley, Noel G. Shoe Essay! Carlson. . (2009) Monoclonal antibody treatments for multiple sclerosis. Essay! Current Treatment Options in Neurology 11 , 211-220. J Ludovic Croxford, Takashi Yamamura. . (2009) Back to robert hass images the future for multiple sclerosis therapy: focus on current and emerging disease-modifying therapeutic strategies. Immunotherapy 1 :3, 403-423. Stephen P Cobbold. . (2009) Future therapeutics for the induction of peripheral immune tolerance in autoimmune disease and organ transplantation.
Immunotherapy 1 :3, 447-460. C. Warnke, B.C. Kieseier, U. Zettl, H-P. Hartung. . (2009) Alemtuzumab als neue Therapieoption der Multiplen Sklerose. Der Nervenarzt 80 , 468-474. A. A. Pace, J. P. Zajicek. . (2009) Melanoma following treatment with alemtuzumab for modern technology essay multiple sclerosis. European Journal of Neurology 16 :10.1111/ene.2009.16.issue-4, e70-e71. Joseph R. Berger, Sidney Houff. . Democracy Essay! (2009) Opportunistic infections and other risks with newer multiple sclerosis therapies. About Modern Technology! Annals of Neurology 65 :10.1002/ana.v65:4, 367-377.
(2009) SEP : nouvel ACM, efficace mais toxique. Revue Francophone des Laboratoires 2009 :411, 21. Howard L. Weiner. . (2009) The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?. Annals of Neurology 65 :10.1002/ana.v65:3, 239-248. Gianluigi Mancardi. . (2009) Further data on simple short essay, autologous haemopoietic stem cell transplantation in multiple sclerosis. The Lancet Neurology 8 , 219-221. Patricia K Coyle. Modern Technology Essay! . (2009) Existing therapies for robert images multiple sclerosis offer proven efficacy and safety. Current Opinion in Neurology 22 , S4-S9. Richard K Burt, Yvonne Loh, Bruce Cohen, Dusan Stefosky, Roumen Balabanov, George Katsamakis, Yu Oyama, Eric J Russell, Jessica Stern, Paolo Muraro, John Rose, Alessandro Testori, Jurate Bucha, Borko Jovanovic, Francesca Milanetti, Jan Storek, Julio C Voltarelli, William H Burns. . (2009) Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. The Lancet Neurology 8 , 244-253. Aimee Pasqua Borazanci, Meghan K Harris, Robert N Schwendimann, Eduardo Gonzalez-Toledo, Amir H Maghzi, Masoud Etemadifar, Nadejda Alekseeva, James Pinkston, Roger E Kelley, Alireza Minagar. . (2009) Multiple sclerosis: clinical features, pathophysiology, neuroimaging and about modern technology, future therapies.
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Matthew Kaufman, Sewanti A. Limaye, Nancy Driscoll, Christina Johnson, Angelica Caramanica, Yehuda Lebowicz, Dilip Patel, Nina Kohn, Kanti Rai. Horn Essay! . (2009) A combination of about essay rituximab, cyclophosphamide and dexamethasone effectively treats immune cytopenias of chronic lymphocytic leukemia. Reflective Essay On Justice! Leukemia Lymphoma 50 , 892-899. (2008) News in about modern technology essay brief. Nature Medicine 14 , 1296-1297. Hauser , Stephen L. , . . (2008) Multiple Lessons for Multiple Sclerosis.
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D. Modern Essay. H. Lawrence Lawrence, D. H. (Twentieth-Century Literary Criticism) - Essay. Lawrence, D. Short. H. 1885-1930. (Full name David Herbert Lawrence. Also wrote under the pseudonym Lawrence H. Davison) English novelist, poet, short story writer, essayist, critic, and translator. The following entry presents criticism of Lawrence's poetry. See also D. H. Lawrence Short Story Criticism and modern essay D. H. Essay. Lawrence Poetry Criticism . Highly acclaimed as a forerunner in adapting psychological themes for literary purposes in such novels as Sons and Lovers, The Rainbow, Women in Love, and Lady Chatterley's Lover, Lawrence's status as a poet is about technology, among the most heatedly disputed topics of twentieth-century literature. Much of the debate stems from the perception that Lawrence published a large quantity of poetry that is often considered very uneven in quality.
Although many of his detractors concede that Lawrence wrote several classic poems, they claim that these works are the exceptions rather than the rule when compared to the bulk of poems Lawrence published. Many of his defenders, however, claim that Lawrence's body of poetry constitutes one unified work in which no one piece can be isolated from the shoe conclusion whole, and that Lawrence's occasional lapses of poetic technique are minor when weighed against his thematic concerns and the instantaneous nature of his poems. His poetic work is often described as visionary, prophetic, and Romantic in intent. Furthermore, Lawrence insisted that his work be read as an about technology essay autobiography as well as a manifesto for the Utopia he envisioned, a new heaven and earth that rejected Victorian prudishness and horn sonata essay rampant industrialization in favor of a more primitive blood-wisdom and sexual freedom. Despite disagreements over his rank among twentieth-century poets, Lawrence's influence is noted in the works of about modern technology such writers as Galway Kinnell, Denise Levertov, Karl Shapiro, Ted Hughes, Adrienne Rich, and Robert Bly. The fourth child of an reflective essay on justice illiterate coal miner and his wife, a former school teacher, Lawrence was raised in the colliery town of Eastwood, Nottinghamshire.
Temperamentally alienated from his environment, he grew to hate the debilitating mine work that he blamed for his father's debased condition. Lawrence won a scholarship to the local grammar school and later to Nottingham University College. He taught school at Coyden for three years, during which time Ford Madox Ford published some of Lawrence's poems in the English Review. The onset of tuberculosis forced Lawrence to modern technology essay, resign from teaching in short essay on computer 1911, and that same year he published his first novel, The White Peacock, which received positive critical reviews. Technology Essay. When he was twenty-seven, Lawrence eloped with Frieda von Richtofen Weekly, the wife of one of his college professors. The couple's erotic and emotional life during their first years together is chronicled in Look! We Have Come Through! After their marriage, the Lawrences lived briefly in Germany, Austria, Italy, Sicily, England, France, Australia, Mexico, and in the southwestern United States, where Lawrence hoped to establish a Utopian community. These locales provided the settings of many of hass essay images his novels written during the 1920s, and essay also inspired his books of travel sketches. In 1930, Lawrence entered a sanitorium in harry potter sorcerer stone Vence, France, in an attempt to cure the tuberculosis that afflicted him throughout his adult life.
He died soon after. Like his fiction, most of Lawrence's poetry is intensely personal. His earliest poetry, which he began writing in about modern technology his twenties, adhered to traditional poetic forms and is seldom as highly regarded as his later free-verse works. His first four volumes— Love Poems and Others, Amores, New Poems, and Bay —display Lawrence's adherence to traditional rhyme schemes. Poems from these volumes were placed by Lawrence in the Rhyming Poems section of The Collected Poems of D. H. Lawrence. These poems are often compared to the poetry of Thomas Hardy, who was an acknowledged influence on Lawrence, in their reliance on regional dialects and subject matter. Look! We Have Come Through! marks a departure in Lawrence's poetics from closed forms to free verse forms that display Lawrence's affinity for the work of American poet Walt Whitman. Birds, Beasts, and Flowers features celebratory and mystical poems about flora and shoe sonata fauna, including his most famous poem, Snake, and the frequently anthologized and discussed Medlars and Sorb Apples. He followed this work with Pansies and about technology Nettles, two works noted for their acerbity and simple essay on computer use of doggerel. Critics note that the poems in the posthumously published Last Poems are preoccupied with death, including the frequently anthologized Bavarian Gentians and The Ship of Death.
Access our D. H. Lawrence Study Guide for Free. The White Peacock (novel) 1911. The Trespasser (novel) 1912. Love Poems and Others (poetry) 1913. The Prussian Officer (short stories) 1914.
The Rainbow (novel) 1915. Amores (poetry) 1916. Twilight in Italy (essays) 1916. Look! We Have Come Through! (poetry) 1917. New Poems (poetry) 1918. The Lost Girl (novel) 1920. Women in Love (novel) 1920.
Psychoanalysis and the Unconscious (essay) 1921. Sea and Sardinia (essays) 1921. Tortoises (poetry) 1921. Aaron's Rod (novel) 1922. England, My England (short stories) 1922. Fantasia of the Unconscious (essay) 1922. Movements in technology essay European History [as Lawrence H. Davison] (essays) 1922. Birds, Beasts and Flowers (poetry) 1923. Kangaroo (novel) 1923. Studies in Classic American Literature (essays) 1923.
Reflections on essay, the Death of a Porcupine (essays) 1925. The Plumed Serpent (novel) 1926. Mornings in Mexico (essays) 1927. The Collected Poems of D. H. Lawrence, 2 vols, (poetry) 1928. Lady Chatterley's Lover (novel) 1928. The Woman Who Rode Away (short stories) 1928. Pansies (poetry) 1929. The Escaped Cock (novella) 1930; also published as The Man Who Died, 1931.
Love among the Haystacks (short stories) 1930. Nettles (poetry) 1930. The Virgin and essay the Gipsy (novel) 1930. Etruscan Places (essay) 1932. Last Poems (poetry) 1932. The Lovely Lady (short stories) 1933. The Ship of Death (poetry) 1933.
A Modern Lover (short stories) 1934. The Spirit of the Place (essays) 1935. Phoenix (essays and criticism) 1936. The First Lady Chatterley (novel) 1944. The Complete Short Stories of D. H. Lawrence, 3 vols.(short stories) 1955.
The Collected Letters of D. Democracy And Media Essay. H. Lawrence, 2 vols, (letters) 1962. The Complete Poems of D. H. Lawrence, 2 vols. (poetry) 1964. The Complete Plays of D. H. Lawrence (drama) 1966. Phoenix II (essays and criticism) 1968. John Thomas and Lady Jane (novel) 1972.
John Gould Fletcher (essay date 1918) SOURCE: A review of Look! We Have Come Through, in Poetry, Vol. XII, No. V, August, 1918, pp. 269-74. [ In the following review of Look! We Have Come Through!
Fletcher praises Lawrence's poetry as uncompromising and original, and finds similarities with the poetry of technology Walt Whitman. ] D. H. Harry Sorcerer Stone. Lawrence has recently published[ Look! We Have Come Through! ] a third volume of about technology essay poetry to stand beside his Love Poems and Amores. Horn Sonata Essay Conclusion. This event has, so far as I am aware, passed almost without notice in the English press. The reviewers of the modern English press know perfectly well that Mr. Lawrence is supposed to be a dangerous man, writing too frankly on certain subjects which are politely considered taboo in good society, and therefore they do their best to prevent Mr. Lawrence from writing at all, by and media essay, tacitly ignoring him. If they are driven to the admission, these selfsame reviewers are obliged grudgingly to acknowledge that Mr. Lawrence is modern essay, one of the robert hass most interesting of modern writers. Modern Essay. Suchare the simple essay on computer conditions which a modern writer with something new to say is obliged to accept in England to-day. The press can make a great to-do about the innocuous, blameless and essentially minor poetry of Edward Thomas (to take but one example); they politely refuse to about essay, discuss the questionable, but essentially major effort of a D. H. Lawrence. Is it any wonder that such an attitude drives a man to sheer fanaticism?
For a fine, intolerant fanatic D. H. Lawrence undoubtedly is. That is democracy and media essay, his value for our present day, so rich in halfmeasures and compromises. Lawrence does not compromise. In this last collection of essay poetry he gives us works which are not good poetry, which are scarcely readable prose. He includes them because they are necessary to essay, the complete understanding of his thought and gospel. We, if we are wise, will read them for the same reason.
For Lawrence is an original thinker, and his message to modern technology essay, our present day is a valuable message. Briefly, the on justice message is this: that everything which we call spiritual is about modern technology, born and atlas essay contest 2012 comes to flower out of certain physical needs and reactions, of which the most patent is the reaction of sex, through which life is maintained on this planet. Lawrence therefore stands in sharp contrast to the Christian dogma of the middle ages, and to about technology essay, those writers of the present day who still maintain an attitude of respect to the Christian view, which is robert essay, that we are each endowed with an immortal soul, at strife with our physical needs, which can only be purged by death. Lawrence, like a recent French writer, does not desire to spit out the forbidden fruit, and recreate the Eden of the refusal of life. Technology. He is frankly pagan. To him, the flesh is the soil in which the spirit blossoms, and the only immortality possible is the setting free of the blossoming spirit from the satiated flesh. When this is accomplished, then the spirit becomes free, perfect, unique, a habitant of paradise on earth.
This is the harry sorcerer doctrine of which he is the about modern technology essay zealot, the robert images intolerant apostle. The specific value of this idea need not concern us very greatly. The question is, rather, of its poetical value; and modern technology essay there is no doubt that it is a system of philosophy which is essentially poetical. (The entire section is 1345 words.) Get Free Access to atlas essay contest, this D. H. About Technology Essay. Lawrence Study Guide. Start your 48-hour free trial to unlock this resource and thousands more. Get Better Grades. Our 30,000+ summaries will help you comprehend your required reading to ace every test, quiz, and essay. We've broken down the chapters, themes, and characters so you can understand them on your first read-through. Access Everything From Anywhere.
We have everything you need in shrugged essay 2012 one place, even if you're on the go. Download our handy iOS app for free. SOURCE: The Melodic Line: D. H. Lawrence, in Scepticisms: Notes on Contemporary Poetry, Alfred A. Knopf, 1919, pp. 91-104. [ In the following essay on about, Lawrence's Look! We Have Come Through! Aiken argues that the simple short essay on computer poem reads more like a novel, and that Lawrence's grasp of poetic techniques are limited. ] It has been said that all the arts are constantly attempting, within their respective spheres, to attain to about modern, something of the quality of music, to assume, whether in pigment, or pencil, or marble, or prose, something of its speed and flash, emotional completeness, and well-harmonied resonance; but of no other single art is that so characteristically or persistently. (The entire section is and media, 2749 words.) Get Free Access to modern, this D. Shrugged Contest 2012. H. Lawrence Study Guide.
Start your 48-hour free trial to unlock this resource and thousands more. SOURCE: Mr. D. H. Lawrence, in Tradition and Change: Studies in Contemporary Literature, Books for about, Libraries Press, 1919, pp. 131-7. [ In the following essay, Waugh assesses Lawrence's poetry as lacking in unifying ideas and the poetic skills necessary to espouse them. ] The modern conception of poetry is so astonishingly different from the conception, for example, of the last generation before our own, that it is worth while to take stock of the situation now and again, and to try to democracy essay, get some clear notion of the direction in about technology essay which we are drifting.
Changes there must be, of democracy course; and the critic who withstands change for its own sake is self-condemned already. Technology. But in. (The entire section is 1684 words.) Richard Aldington (essay date 1926) SOURCE: D. H. Atlas Shrugged Essay Contest 2012. Lawrence as Poet, in The Saturday Review of technology essay Literature, New York, Vol. Images. 11, No.
40, May 1, 1926, pp. 749-50. [ In the following overview of Lawrence 's poetry, including Birds, Beasts, and Flowers, Aldington attempts to cast aside the poet's ideology and sexual subject matter in order to isolate the poetry he writes, which Aldington believes to be representative of its author's genius. ] If a difficult problem were being set for about modern essay, what Mr. Bennett calls the young aspirant in criticism, there could scarcely be found a better topic than Mr. D. H. Lawrence. He is not the sort of man who becomes master of Balliol or an essay 2012 Oracle to thoughtful, cautious. (The entire section is 1349 words.) SOURCE: D. H. Lawrence and Expressive Form, in about technology Language as Gesture: Essays in Poetry, Harcourt, Brace and Company, 1935, pp. 286-300.
[In the following essay, Blackmur argues that Lawrence's poetry is too often marred by the author's unchecked inclusion of biographical detail and personal feelings.] As a poet, and only to a less degree as a novelist, Lawrence belongs to that great race of English writers whose work totters precisely where it towers, collapses exactly in its strength: work written out of a tortured Protestant sensibility and upon the foundation of an incomplete, uncomposed mind: a mind without defenses against the material with which it builds and. (The entire section is 5466 words.) SOURCE: An introduction to D. H. Lawrence: Selected Poems, New Directions, 1947, pp. 1-23. [In the following introduction to Lawrence's Selected Poems, Rexroth believes that, rather than being a major poet like Thomas Hardy, Lawrence was a minor prophet like William Blake and William Butler Yeats.] At the very beginning Lawrence belonged to simple on computer, a different order of being from the literary writers of modern his day. In 1912 he said: I worship Christ, I worship Jehovah, I worship Pan, I worship Aphrodite. But I do not worship hands nailed and running with blood upon a cross, nor licentiousness, nor lust.
I want them all, all the essay harry potter stone gods. They are all God. But I must serve in. (The entire section is 7207 words.) Charles I. Glicksberg (essay date 1948)
SOURCE: The Poetry of D. About Modern. H. Lawrence, in The New Mexico Quarterly Review, Vol. 14, March 13, 1948, pp. 289-303. [ In the following essay, Glicksberg examines Lawrence's poetry to support his thesis that Lawrence was engaged in creating his own religion that eschewed science and short materialism. ] There is no contradiction in the fact that Lawrence's ideas on human nature and society are muddled while his poetry is flame-like, instinct with beauty organically felt and sensuously communicated. When he trusted his feelings he was on firm ground; when his powerful sensibility ruled him he could not go wrong. Each impression leaped forth like a radiant beam of sunlight; form. (The entire section is about, 6064 words.)
SOURCE: D. H. Lawrence, in democracy and media The Dyer's Hand and Other Essays, Random House, 1948, pp. Modern Technology. 277-95. [ In the shoe sonata following essay, Auden echoes Richard Aldington's assessment that readers should not read Lawrence to reinforce ideologies — which are better expressed elsewhere by other writers — and about that his genius lay in his ability to articulate humankind's aggressive and hateful natures. ] The artist, the man who makes, is less important to mankind, for good or evil, than the apostle, the man with a message. Horn. Without a religion, a philosophy, a code of behavior. (The entire section is 6262 words.) George G. Modern. Williams (essay date 1951) SOURCE: D. H. Essay On Justice. Lawrence's Philosophy as Expressed in His Poetry, in The Rice Institute Pamphlet, Vol. XXXVIII, No. 2, July, 1951, pp. Essay. 73-94. [ In the following essay, Williams proposes that the body of sorcerer stone Lawrence 's poetical works must be read in modern order to simple short, give a full understanding of the author's philosophical and sociological intent. ] I. A NEGLECTED POETRY.
Books by D. H. Lawrence would fill a good-sized shelf, and books about him would fill an even larger shelf. Ten years after his death an editorial writer in the Saturday Review of Literature said that he has been the subject of about technology essay more books than any other writer since. (The entire section is essay sorcerer stone, 5781 words.) SOURCE: Lawrence's Collected Poems: The Demon Takes Over, in PMLA, Vol. 66, 1951, pp. 583-93.
[ In the following essay, Bartlett examines the nature and breadth of Lawrence's revisions of his earlier poems for the 1928 Collected Poems.] It is well known that D. H. Lawrence was an unsparing rewriter of about modern his fiction, and the tradition persists that he could never revise, he could only rewrite. Yet, although he rewrote a number of poems, as he did his short stories and novels, he revised many more—nearly all of them, in fact, either before or after publication. His most concentrated period of essay activity as a poetic reviser was the winter of 1927-28, when he collected. (The entire section is 4821 words.) SOURCE: Peace and Passivity: The Poetry of D. H. Lawrence, in The South Atlantic Quarterly, Vol. 55, 1956, pp.
337-48. [ In the following essay, Fisher examines what he believes is the paradoxical nature of Lawrence's poetry. ] To read the about essay poems of D. H. Lawrence after knowing his novels and other prose is to confront the shrugged essay contest 2012 paradox of the romantic. The rebellious individualism which distinguishes Lawrence's fiction is inverted in about technology essay the poetry into essay, a continuing desire to be merged, to be soothed into some harmonious and self-obliterating whole. Essay. In contrast with the turbulent fiction, Lawrence's poetry is generally temperate, expressing a craving for an oblivion, for an. (The entire section is 3691 words.) SOURCE: Comment: Reflections on Lawrence, in Poetry, Vol. Hass Essay. 106, 1965, pp. 218-25.
[ In the following review of The Complete Poems of D.H. About Modern. Lawrence, Rich assesses Lawrence as a major poet, finding evidence that Lawrence deliberately reduced many poems to doggerel for effect, and arguing that Lawrence is the English language's best love poet since William Shakespeare. Democracy Essay. ] Thought, he says in More Pansies, is a man in his wholeness wholly attending. Have his readers wholly attended to him? But, my dear God, when I see all the understanding and suffering and the pure intelligence necessary for the simple perceiving of poetry, then I know it is an almost. (The entire section is technology essay, 2806 words.) SOURCE: D. H. Lawrence's Last Poems, in The D. H. Essay Contest 2012. Lawrence Review, Vol. About Modern Technology. 5, No.
2, Summer, 1972, pp. 97-120. [ In the following essay, Kirkham examines Lawrence's Last Poems as a poetic sequence with consistent themes and execution. ] This essay falls into three parts. In the first part I suggest that Last Poems is best read as a single work, forming a loosely connected sequence of thought. I see Lawrence performing an act of spiritual preparation, the directing purpose of which is to construct a state of mind that will steady him in the face of death.
In the second part I discuss the central themes of the sequence. I try to show that, though much of the. (The entire section is 8693 words.) SOURCE: 'Secret Sin': Lawrence's Early Verse, in The D. H. Lawrence Review, Vol. Simple Essay On Computer. 8, No.
2, Summer, 1975, pp. 155-75. [ In the following essay, Shakir examines Lawrence's early poems for evidence of his sexual preoccupations. ] Throughout his career as a writer, Lawrence's attitude toward literature was remarkably ambivalent. Artspeech is the only truth, he declared (SCAL 2). 1 Yet his mistrust of art was profound. He knew how easily it could degenerate into technology essay, pretty artifice or aesthetic exercise and so seduce the artist into a lie. But when literature spoke truth, it was perhaps most dangerous and robert the artist finally most guilty. An examination of. (The entire section is 7110 words.) SOURCE: D. H. Lawrence and about modern technology the Resources of Poetry, in Language and Style, Vol. Democracy And Media Essay. XII, No.
1, Winter, 1979, pp. 3-12. [ In the following essay, Presley examines Lawrence's deployment of free verse and its relationship to the themes of his poetry. ] The poetry of D. H. Lawrence presents an interesting problem for stylistic investigation. Nearly all critics agree that Lawrence evolved a new form; that, from a mediocre Georgian lyricist, he became a sometimes excellent free-verse lyricist. Though his mature work has been widely influential, especially in America, his poetry is often treated as an adjunct to the novels, and has received little detailed examination.
(The entire section is 4241 words.) SOURCE: The Psychological Dynamics of D. H. Lawrences's 'Snake', in American Imago, Vol. 36, No. Technology Essay. 4, Winter, 1979, pp. 345-56. [ In the following essay, Trail employs Freudian psychology to simple short essay, explicate Lawrence's poem The Snake. ] Snake is D. Modern. H. Lawrence's best known poem. Essay Harry. It is not only the most anthologized (and hence the most taught) but also the most analyzed. A glance at the poem itself provides some immediate, if only surface, explanations: The poem has a narrative line. About. A man, on a hot noon in Italy, comes to fill his water pitcher from a trough and finds a snake there. For an interval, in spite of the voice of his education which tells him.
(The entire section is 4407 words.) SOURCE: Hymn to on computer, Priapus: Lawrence's Poetry of Difference, in Criticism, Vol. XXII, No. 3, Summer, 1980, pp. 214-29. [ In the following essay, Murfin finds similarities and differences between Lawrence's Hymn to about technology, Priapus and works by Charles Algernon Swinburne and Thomas Hardy. ] The speaker of the Hymn to Priapus, like the speakers in all the other lyrics in D. Robert Essay Images. H. Lawrence's volume of modern technology poems entitled Look! We Have Come Through!, may be taken to be Lawrence himself. He tells us he danced at a Christmas party/Under the mistletoe Along with a ripe, slack country lass. Jostling to and fro. (The entire section is 5981 words.)
SOURCE: D. H. Lawrence's Uncommon Prayers, in D. H. Essay. Lawrence: The Man Who Lived, edited by Robert B. Partlow, Jr., and modern essay Harry T. Reflective Essay. Moore, Southern Illinois University Press, 1980, pp. About Technology. 73-93. [ In the following essay, Gilbert agrees with T. S. Eliot's assessment of Lawrence as a hater of orthodoxy, but disagrees with Eliot when he negatively evaluates Lawrence's moral canon. ] . . . we've got the democracy world inside out. The true living world of essay fire is dark, throbbing, darker than blood. Our luminous world that we go by is only the essay reverse of this.
—Count Johann Dionys Psanek, in The Ladybird (The entire section is 11197 words.) SOURCE: 'Not I, but the Wind That Blows Through Me': Shelleyan Aspects of Lawrence's Poetry, in Texas Studies in Literature and Language, Vol. 23, No. About Essay. 1, Spring, 1981, pp. 102-22. [ In the essay harry sorcerer stone following essay, Rubin discusses resemblances between the poetry of Lawrence and Percy Bysshe Shelley. Modern. ] Despite Lawrence's strenuous denials of influence, specific influences upon his poetry are clearly discernible. In addition to Whitman, Wordsworth, and Blake, 1 other influences were the King James Bible, the Nonconformist hymns of sonata Lawrence's chapel youth, and the poetry of the technology essay Pre-Raphaelites, Swinburne, and Hardy. The early love poems are faintly Pre-Raphaelite in.
(The entire section is 8988 words.) SOURCE: D. H. Lawrence, Major Poet, in on justice Texas Studies in Literature and essay Language, Vol. 26, No. Short. 3, Fall, 1984, pp. 303-30. [In the following essay, Poole attempts to modern technology essay, defend Lawrence as a major poet fully in control of poetic technique.]
Over the years, a number of studies of Lawrence's poetry have appeared, though by no means as many as his merits suggest, and it is astonishing that the reflective essay on justice Open University's third-level course on twentieth-century poetry 1 not only omits Lawrence from the poets studied, but manages to about modern technology, accord him little more than a passing mention. Nevertheless, some good studies have appeared, but the shoe sonata conclusion emphasis has hardly been on. (The entire section is 11594 words.) SOURCE: D. H. Lawrence—The Poetry, in Contemporary Review, Vol. About Modern Technology. 247, No. 1438, November, 1985, pp. 257-60. [ In the following essay, Vanson argues that Lawrence was a master craftsman, and places him alongside such poets as Gerard Manley Hopkins, Percy Bysshe Shelley, and Robert Browning, while finding him not equal to harry potter sorcerer stone, Virgil, Dante, and Shakespeare. ] At the time of the Lady Chatterley obscenity trial in an article for a provincial newspaper I suggested that in time to come (i.e. now!) the real fame of D. H. Lawrence would derive not from his novels but from his poetry. Time has proved me wrong, for there are today probably a hundred readers of The. (The entire section is 1641 words.) Aiken, Conrad.
Collected Criticism (Formerly 'A Reviewer's ABC). London: Oxford University Press, 1935, 414 p. Essays written by Aiken on Lawrence between 1924 and 1929 that evidence Aiken's admiration for Lawrence as a prose writer as well as his reservations concerning the about technology essay prosaic nature of Lawrence's verse. Baker, James R. Lawrence as Prophetic Poet. Journal of Modern Literature 3, No.
5 (July 1974): 1219-38. Discusses Lawrence's poetry and the works of W. B. Yeats, Robinson Jeffers, and T. S. Eliot, finding prophetic qualities in the work of and media essay all four poets. Brashear, Lucy M. Lawrence's. (The entire section is 781 words.) D. H. About Modern Technology. Lawrence Homework Help Questions.
“Money-Madness,” written by D. H. Lawrence in the 1920s, has a message that is appropriate for the world today. In the Asian, African and Latin American countries, well over 500 million. It is ironic that, in Last Lesson of the shoe horn conclusion Afternoon by D H Lawrence, it is the teacher who is waiting for the school bell to ring to end this weariness and not the students. The children he is. Line by line is a little difficult, but I will explain each stanza. This poem takes place in about Sicily, an island in the Mediterranean Sea, near Italy. Stanza 1: A snake comes to robert essay images, the watering.
This is about technology, one of those questions which can and should receive a variety of responses for and media, two reasons. First, there is no definitive list of about modern technology Lawrence's poetry (or most poets, for that matter) in. Perspective is introduced into this poem by the persona that Lawrence creates who speaks the words that any teacher can perhaps identify with at times. The persona of simple on computer this poem is a teacher.